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- W2977368081 abstract "Objective To analyze expression of MicroRNA let-7 and matrix metalloproteinases 2(MMP-2)and their clinical significance and to discusses their role in non-small cell lung cancer(NSCLC)and correlation during lung carcinogenesis.Methods MMP-2 expression was determined using immunohistochemical SP and Western blot,and clinicopathological features were analyzed.Realtime quantitative PCR analysis was conducted to detect let-7 and MMP-2 expression,and the relationship between let-7 and MMP-2 was analyzed.Results The immunohistochemisty results showed among 46 NSCLC,MMP-2 was stained positively in 30 cases(65.2%).Expression of MMP-2 in NSCLC did not show significant difference between pathological type,age and sex(P0.05).The positive expression of MMP-2 was associated with tumor stage and lymph node metastasis(P0.05).Western blot analysis showed that MMP-2 protein expression was significantly higher in lung cancer tissue,compared with those in paraneoplastic tissue.Realtime quantitative PCR analysis showed that let-7 lower expression for 29 cases(63%);MMP-2 higher expression for 31 cases(67.4%).Spearman′s correlation revealed that MMP-2 expression was correlated negatively with let-7 in 46 lung cancer specimens(rs=-0.433,P0.05).Conclusions Our result indicated that let-7 and MMP-2 maybe involved in lung cancer and may imply coordination in lung tumorigenesis." @default.
- W2977368081 created "2019-10-10" @default.
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- W2977368081 date "2012-01-01" @default.
- W2977368081 modified "2023-09-23" @default.
- W2977368081 title "Expression and correlation of microRNA let-7 and MMP-2 in non-small cell lung cancer" @default.
- W2977368081 hasPublicationYear "2012" @default.
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