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• W2977371330 abstract "Introduction: Recently, clostridium difficile infection (CDI) has become a major public health infectious agent because of the hypervirulent strain 027/BI/NAP. CDI is now the leading cause of antibiotic associated diarrhea, both nosocomial and community-associated. Due to the increased morbidity, mortality and economic burden of CDI, there is great need to understand the patient demographics to define risk factors associated with this disease. Our study's aim is to retrospectively analyze records of patients hospitalized with CDI at Hahnemann University Hospital, an urban acute care hospital in Philadelphia, PA, and compare it with USA patient characteristics. Methods: For each patient admitted to HUH with a new diagnosis of CDI between July 2014 and December 2015, we determined the following: age, gender, admission date, CDI diagnosis date, chronic co-morbidities. CDI diagnosis is based on positive CDI diagnostic test (C. DIFF QUIK CHEK COMPLETETM, Cepheid GeneXpert, CDIFF/EPI PCR test) performed at HUH clinical laboratory. Hospital-acquired CDI was defined as positive laboratory diagnosis on or after 72 hours post-admission with diagnosis earlier than 72 hours defined as community-acquired. Results: Between July 2014 to December 2015, 280 patients were admitted with newly diagnosed CDI, with 54% male and 46% female. National data revealed female predominance at 59%. Both at HUH and nationally, males were more commonly infected in hospital-acquired cases while females have higher percentage in community-acquired. At HUH, the largest age cohort was aged 45-64, while nationally, 51.9% of CDI occur in patients over 65 years. There was also an African American predominance at HUH (52.2%) with national data revealing 78.6% Caucasian. Overall 8.1% of HUH cases were coinfected with HIV and 14.2% with HCV. Conclusion: Our data suggest that HUH has a unique cohort of CDI+ cases that differs from the national average in age, gender and race. At an urban hospital, CDI patients are younger with gender distribution roughly even, suggesting gender is not a risk factor. Discrepancy in age and race can be attributed to the hospital's center-city location. With differences in HUH's cohort of CDI+ cases compared to nationally, further patient risk data should be assessed to identify co-morbid conditions that lead to increased incidence of CDI at our urban hospital. These data will lead to a clinical prediction tool for CDI that could be used to identify patients at risk for acquisition of this infection.Figure 1Figure 2Figure 3" @default.
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• W2977371330 date "2016-10-01" @default.
• W2977371330 modified "2023-09-27" @default.
• W2977371330 title "Demographics of Patients Infected with Clostridium Difficile at an Urban Hospital Reveal Higher Numbers of Younger Males at Risk" @default.
• W2977371330 doi "https://doi.org/10.14309/00000434-201610001-02384" @default.
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