FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2977374807> ?p ?o ?g. }

• W2977374807 endingPage "2996" @default.
• W2977374807 startingPage "2986" @default.
• W2977374807 abstract "The subcutaneous administration route is widely used to administer different types of drugs given its high bioavailability and rapid onset of action. However, the sensation of pain at the injection site might reduce patient adherence. Apart from a direct effect of the drug itself, several factors can influence the sensation of pain: needle features, injection site, volume injected, injection speed, osmolality, viscosity and pH of formulation, as well as the kind of excipients employed, including buffers and preservatives. Short and thin needles, conveniently lubricated and with sharp tips, are generally used to minimize pain, although the anatomic injection site (abdomen versus thigh) also affects the sensation of pain. Large subcutaneous injection volumes are associated with pain. In this sense, the maximum volume generally accepted is around 1.5 ml, although volumes of up to 3 ml are well tolerated when injected in the abdomen. Injected volumes of up to 0.5-0.8 ml are not expected to increase substantially the pain produced by the needle insertion. Ideally, injectable products should be formulated as isotonic solutions (osmolality of about 300 mOsm/kg) and no more than 600 mOs/kg have to be used in order to prevent pain. A pH close to the physiological one is recommended to minimize pain, irritation, and tissue damage. Buffers are frequently added to parenteral formulations to optimize solubility and stability by adjusting the pH; however, their strength should be kept as low as possible to avoid pain upon injection. The data available recommend the concentration of phosphate buffer be limited to 10 mM and that the concentration of citrate buffer should be lower than 7.3 mM to avoid an increased sensation of pain. In the case of preservatives, which are required in multiple-dose preparations, m-cresol seems to be more painful than benzyl alcohol and phenol.Funding: Sandoz SA." @default.
• W2977374807 created "2019-10-10" @default.
• W2977374807 creator A5070122487 @default.
• W2977374807 creator A5070288537 @default.
• W2977374807 creator A5070967251 @default.
• W2977374807 creator A5083239532 @default.
• W2977374807 date "2019-10-05" @default.
• W2977374807 modified "2023-10-16" @default.
• W2977374807 title "Subcutaneous Injection of Drugs: Literature Review of Factors Influencing Pain Sensation at the Injection Site" @default.
• W2977374807 cites W1187117804 @default.
• W2977374807 cites W1505566231 @default.
• W2977374807 cites W1841839036 @default.
• W2977374807 cites W1842634657 @default.
• W2977374807 cites W1863389022 @default.
• W2977374807 cites W1975107434 @default.
• W2977374807 cites W1979364075 @default.
• W2977374807 cites W2009776630 @default.
• W2977374807 cites W2014837879 @default.
• W2977374807 cites W2017534125 @default.
• W2977374807 cites W2019755662 @default.
• W2977374807 cites W2021907443 @default.
• W2977374807 cites W2027397388 @default.
• W2977374807 cites W2047993914 @default.
• W2977374807 cites W2049430789 @default.
• W2977374807 cites W2056916052 @default.
• W2977374807 cites W2057109685 @default.
• W2977374807 cites W2064806601 @default.
• W2977374807 cites W2086246083 @default.
• W2977374807 cites W2091447598 @default.
• W2977374807 cites W2092665065 @default.
• W2977374807 cites W2101638417 @default.
• W2977374807 cites W2106357609 @default.
• W2977374807 cites W2113486600 @default.
• W2977374807 cites W2117648045 @default.
• W2977374807 cites W2132319148 @default.
• W2977374807 cites W2150760778 @default.
• W2977374807 cites W2152026434 @default.
• W2977374807 cites W2163972237 @default.
• W2977374807 cites W2166160396 @default.
• W2977374807 cites W2170378739 @default.
• W2977374807 cites W2184881411 @default.
• W2977374807 cites W2381038661 @default.
• W2977374807 cites W2475096707 @default.
• W2977374807 cites W2513381414 @default.
• W2977374807 cites W2518909465 @default.
• W2977374807 cites W2750524685 @default.
• W2977374807 cites W2763510211 @default.
• W2977374807 cites W2789287250 @default.
• W2977374807 cites W2809293243 @default.
• W2977374807 cites W2886138990 @default.
• W2977374807 cites W338456458 @default.
• W2977374807 cites W4243568083 @default.
• W2977374807 doi "https://doi.org/10.1007/s12325-019-01101-6" @default.
• W2977374807 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6822791" @default.
• W2977374807 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31587143" @default.
• W2977374807 hasPublicationYear "2019" @default.
• W2977374807 type Work @default.
• W2977374807 sameAs 2977374807 @default.
• W2977374807 citedByCount "103" @default.
• W2977374807 countsByYear W29773748072020 @default.
• W2977374807 countsByYear W29773748072021 @default.
• W2977374807 countsByYear W29773748072022 @default.
• W2977374807 countsByYear W29773748072023 @default.
• W2977374807 crossrefType "journal-article" @default.
• W2977374807 hasAuthorship W2977374807A5070122487 @default.
• W2977374807 hasAuthorship W2977374807A5070288537 @default.
• W2977374807 hasAuthorship W2977374807A5070967251 @default.
• W2977374807 hasAuthorship W2977374807A5083239532 @default.
• W2977374807 hasBestOaLocation W29773748071 @default.
• W2977374807 hasConcept C130093455 @default.
• W2977374807 hasConcept C136229726 @default.
• W2977374807 hasConcept C141071460 @default.
• W2977374807 hasConcept C169760540 @default.
• W2977374807 hasConcept C181389837 @default.
• W2977374807 hasConcept C203014093 @default.
• W2977374807 hasConcept C2777063393 @default.
• W2977374807 hasConcept C2779983558 @default.
• W2977374807 hasConcept C3018125106 @default.
• W2977374807 hasConcept C42219234 @default.
• W2977374807 hasConcept C71924100 @default.
• W2977374807 hasConcept C86803240 @default.
• W2977374807 hasConcept C98274493 @default.
• W2977374807 hasConceptScore W2977374807C130093455 @default.
• W2977374807 hasConceptScore W2977374807C136229726 @default.
• W2977374807 hasConceptScore W2977374807C141071460 @default.
• W2977374807 hasConceptScore W2977374807C169760540 @default.
• W2977374807 hasConceptScore W2977374807C181389837 @default.
• W2977374807 hasConceptScore W2977374807C203014093 @default.
• W2977374807 hasConceptScore W2977374807C2777063393 @default.
• W2977374807 hasConceptScore W2977374807C2779983558 @default.
• W2977374807 hasConceptScore W2977374807C3018125106 @default.
• W2977374807 hasConceptScore W2977374807C42219234 @default.
• W2977374807 hasConceptScore W2977374807C71924100 @default.
• W2977374807 hasConceptScore W2977374807C86803240 @default.
• W2977374807 hasConceptScore W2977374807C98274493 @default.
• W2977374807 hasFunder F4320333100 @default.
• W2977374807 hasIssue "11" @default.
• W2977374807 hasLocation W29773748071 @default.

• next