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• W2977389456 endingPage "20180442" @default.
• W2977389456 startingPage "20180442" @default.
• W2977389456 abstract "Evidence of ageing in the bacterium Escherichia coli was a landmark finding in senescence research, as it suggested that even organisms with morphologically symmetrical fission may have evolved strategies to permit damage accumulation. However, recent work has suggested that ageing is only detectable in this organism in the presence of extrinsic stressors, such as the fluorescent proteins and strong light sources typically used to excite them. Here we combine microfluidics with brightfield microscopy to provide evidence of ageing in E. coli in the absence of these stressors. We report (i) that the doubling time of the lineage of cells that consistently inherits the ‘maternal old pole’ progressively increases with successive rounds of cell division until it reaches an apparent asymptote, and (ii) that the parental cell divides asymmetrically, with the old pole daughter showing a longer doubling time and slower glucose accumulation than the new pole daughter. Notably, these patterns arise without the progressive accumulation or asymmetric partitioning of observable misfolded-protein aggregates, phenomena previously hypothesized to cause the ageing phenotype. Our findings suggest that ageing is part of the naturally occurring ecologically-relevant phenotype of this bacterium and highlight the importance of alternative mechanisms of damage accumulation in this context. This article is part of a discussion meeting issue ‘Single cell ecology’." @default.
• W2977389456 created "2019-10-10" @default.
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• W2977389456 date "2019-10-07" @default.
• W2977389456 modified "2023-10-14" @default.
• W2977389456 title "Bacterial ageing in the absence of external stressors" @default.
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• W2977389456 doi "https://doi.org/10.1098/rstb.2018.0442" @default.
• W2977389456 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6792439" @default.
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• W2977389456 hasPublicationYear "2019" @default.
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