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- W2977394720 abstract "Abstract Background Esophageal squamous cell carcinoma (ESCC) is one of the most common cancers in china. Because the disease often has no symptoms in the early stages, it is usually detected at a more advanced stage that is more challenging to treat. The inter-communication between esophageal squamous cell carcinoma and its surrounding microenvironment is essential for tumor progression and metastasis. Exosome plays a key role in information delivery between primary lesion and pre-metastatic niche via its packed bioactive molecules. The aim of this study is to explore the effect of exosome from tumor plasma to angiogenesis in human lymphatic endothelial cells (HLEC) in vitro. Methods Total circulation exosomes (CEs) were extracted and purified to selectively capture EpCAM positive exosomes by magnetic-bead technique. Proteins were separated by SDS-PAGE, and protein bands were analyzed by mass spectrometry. Tube formation assay and fluorescence imaging assay were performed in vitro. Results The expression level of CEs in ESCC patients with lymph node metastasis were significantly higher than that in ESCC patients without metastasis and healthy control group (respectively; P Conclusions Exosomes released by ESCC may play important roles in the microenvironment of ESCC and provide a potential application of therapy. Legal entity responsible for the study Zhejiang Cancer Hospital. Funding NSFC. Disclosure All authors have declared no conflicts of interest." @default.
- W2977394720 created "2019-10-10" @default.
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- W2977394720 date "2019-10-01" @default.
- W2977394720 modified "2023-09-23" @default.
- W2977394720 title "The study of tumor associated exosomes in crosstalk between esophageal carcinoma and lymphatic endothelial cells" @default.
- W2977394720 doi "https://doi.org/10.1093/annonc/mdz266.019" @default.
- W2977394720 hasPublicationYear "2019" @default.
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