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- W2977395951 abstract "Prenatal diagnosis of coarctation of the aorta (CoA) is affected by high false-positive and false-negative rates. The aim of this study was to identify sonographic criteria to improve identification of fetal CoA. A retrospective review was conducted on subjects with a prenatal suspicion for CoA. 69 subjects were identified with prenatal suspicion for CoA. 47 normal fetuses were selected as the control group. Retrospective measurements of RV/LV ratio, PA/AO ratio, aortic isthmus (AOI) Z-scores, diastolic velocity time integral (VTID) and systolic velocity time integral (VTIS) at the AOI were recorded. ROC analysis identified the parameter most predictive of postnatal CoA. When comparing subjects with (n = 31) and without CoA (n = 38), significant difference were detected for AOI Z-scores, VTID, VTID/VTIS ratio and VTID/(VTID+VTIS) ratio (P<0.001). The AUC are summarised in table 1 in detail. There was 25% (95%CI:0.14,0.35) improvement in the AUC after adding VTID/VTIS ratio to the basic model (AOI Z-score (sagittal view)). VTID/VTIS ratio showed significantly better discrimination and reclassification ability for determining CoA. PA/AO ratio, VTID, VTID/VTIS ratio and VTID/(VTID+VTIS) ratio were stable throughout the normal fetal development period in our study. In cases with suspected prenatal diagnosis of CoA, evaluation of spectral Doppler, such as VTID/VTIS ratio, may enhance the accuracy of diagnosis with fetal echocardiography. OC17.03: Table 1. Data from the ROC curves" @default.
- W2977395951 created "2019-10-10" @default.
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- W2977395951 date "2019-09-30" @default.
- W2977395951 modified "2023-10-16" @default.
- W2977395951 title "OC17.03: The diastolic and systolic velocity time integral ratio of aortic isthmus is a sensitive indicator of aortic coarctation in fetuses" @default.
- W2977395951 doi "https://doi.org/10.1002/uog.20536" @default.
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