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- W2977414862 abstract "Introduction: Neutropenic enterocolitis is a life threatening condition, primarily seen in patients with hematologic malignancies undergoing chemotherapeutic regimen. The true incidence and frequency for neutropenic enterocolitis is thought to be underestimated. In addition, there is a paucity of data on the demographics and prevalence of complications in patients with neutropenic enterocolitis. In this study we aimed to determine the prevalence of neutropenic enterocolitis in patients with leukemia admitted nationwide to US hospitals between 2006-2010. We also aimed to assess the mortality rates and prevalence of associated complications such as perforation, peritonitis, disseminated intravascular coagulation (DIC) and sepsis. Methods: We queried a United States national in-patient database for the years 2006-2010. All patients with diagnosis of leukemia were identified from the National Inpatient sample (NIS) database from 2006-2010 using the 9th revision of the International Classification of Disease (ICD) codes 205.0x for acute myeloid leukemia, 205.1x for chronic myeloid leukemia, 204.0x for acute lymphoid leukemia and 204.1x for chronic lymphoid leukemia. Subsequently all neutropenic patients with enterocolitis were extracted from them. Results: Of 853,080 patients with leukemia, the prevalence of neutropenic enterocolitis was 0.35% (n=3,019), the mean age was 41.4±0.9 years, of which 48% were females. Mean length of hospital stay was 23.9±0.9 days and in-hospital mortality rate was 5.7%. No statistically significant difference in mortality rate was observed in males and females (6.4 versus 4.8%; p=0.46). Complications prevalent in our study were - sepsis 9.4%, gastrointestinal bleeding 6.1%, DIC 3.5%, acute peritonitis 0.3% and intestinal perforation 0.2%. Conclusion: Neutropenic enterocolitis is a growing concern in leukemic patients with substantial morbidity and mortality." @default.
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- W2977414862 date "2016-10-01" @default.
- W2977414862 modified "2023-09-27" @default.
- W2977414862 title "Morbidity and Mortality of Neutropenic Enterocolitis in Leukemia Patients: National Trends and In-hospital Outcomes" @default.
- W2977414862 doi "https://doi.org/10.14309/00000434-201610001-00942" @default.
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