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- W2977498104 abstract "Objective: To elementary screen aging diabetes Mellitus(DM) rats model induced by artificial technology.Methods: After peritoneal injection with D-galactose,the Wistar female rats were feeded with different periodical enriched diet and intraperitoneal injected with different doses Streptozotocin(STZ).The bloods were collected to test fasting blood glucose(FBG),superoxide dismutase(SOD),maleic dialdehyde(MDA) and the issue of pancreatic gland was exteriorized to prepare pathological section to further observe.Results: ① There were no significant differences of the modeling rate among all groups.② All aged DM Rats' FBG and MDA were raised,and SOD was down regulated.③ The results of pancreas pathological section showed that pancreatic islet cell mass of all DM groups rats was 22.93%-44.51%(P0.01) compared with the normal control group,the bound of pancreatic islet was unclear,the arrangements of islet cells were unregulated,islet cells were alveolated,and islet cells quantity reduced markedly.Conclusion: ① DM rats model could be induced by different artificial methods.② Aged DM rats model induced by which combined with D-galactose intraperitoneal injection for 42 days,enriched diet for 6 weeks and STZ intraperitoneal injection twice was the ideal one." @default.
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- W2977498104 date "2012-01-01" @default.
- W2977498104 modified "2023-09-26" @default.
- W2977498104 title "Study on experimental aged diabetes mellitus rats model" @default.
- W2977498104 hasPublicationYear "2012" @default.
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