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- W2977501946 abstract "Lead is one of the most environmental toxic metals.The present study was conducted to investigate the protective role of naringenin against lead-induced damage in rat blood and brain. SD male rats were randomly divided into 4groups,control group,naringenin-treated group,leadtreated group and lead+naringenin-treated group,respectively.After eight weeks,rats were killed,blood and brain were collected.The red blood cell(RBC)count and the haemoglobin(Hb) concentration were determined.The levels of MDA,GSH,SOD and CAT content in brain were measured.The results showed that lead caused a significant reduction in RBC and Hb.Lead induced oxidative stress in brain tissue,which was indicated by the significantly(P0.01)increased level of maleic dialdehyde(MDA)and decreased levels of reduced glutathione(GSH),superoxide dismutase(SOD)and catalase(CAT)(P0.01or P0.05).Naringenin alone did not induce any significant change in biochemical parameters of blood and brain tissues.Compared the naringenin antagonistic groups with the poisoning groups,the levels of RBC and Hb in blood of rat increased significantly(P0.05),the levels of MDA in brain increased significantly(P 0.05).The content of GSH and the activity of SOD,CAT increased significantly(P0.05).The results suggested that naringenin exhibited remarkably protective effects on lead-induced stress in blood and brain of rats." @default.
- W2977501946 created "2019-10-10" @default.
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- W2977501946 date "2014-01-01" @default.
- W2977501946 modified "2023-09-23" @default.
- W2977501946 title "Protective effect of naringenin against lead-induced damage in blood and brain of rat" @default.
- W2977501946 hasPublicationYear "2014" @default.
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