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- W2977536175 abstract "Objective:To explore the possible mechanism of Qianliejian by the expressions of IL-1β and COX-2 protein in experimental chronic abacterial prostatitis rats prostate tissue.Methods:The experimental chronic abacterial prostatitis rat models were induced refered to Seethalakshm's method.And 3-month-old male Wistar rats were divided into four groups randomly:the normal group,the model group,the treat group and the control group,with 10 cases in each group.The treat group was given Qianliejian decoction 1 milliliter per 100 gram avoirdupois(comprise crude drug 1.13 gram per milliliter);the control group was given Qianlietongyu decoction 1 milliliter per 100 gram avoirdupois;the normal group and the control group were given the same dosage of normal saline.All animals were killed after 30 days' treatment,and prostate glands were obtained and the expressions of IL-1β and COX-2 protein were measured with the method of immunohistochemistry.Results:The expressions of IL-1β and COX-2 protein were markedly increased in the model group,compared to the normal group,the difference had statistical significance(P0.01).Compared to the model group,the expressions of IL-1β and COX-2 protein in treatment group and control group were markedly decreased,the difference had statistical significance(P0.01,P0.05).The expressions of IL-1β and COX-2 protein in the treatment group were fewer than that in the control group(P0.05).Conclusion:Qianliejian can decrease the expressions of IL-1β and COX-2 which are closely related to inflammation and fibroplasias,this may be one of the mechanisms of Qianliejian treating chronic abacterial prostatitis." @default.
- W2977536175 created "2019-10-10" @default.
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- W2977536175 date "2012-01-01" @default.
- W2977536175 modified "2023-09-23" @default.
- W2977536175 title "Effect of Qianliejian on the Expressions of IL-1β and COX-2 Levels in the Rat Model of Chronic Abacterial Prostatitis" @default.
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