FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2977563485> ?p ?o ?g. }

• W2977563485 endingPage "223" @default.
• W2977563485 startingPage "220" @default.
• W2977563485 abstract "Combined antiretroviral therapy (cART) consisting of two nucleoside reverse transcriptase inhibitors (NRTIs) and one non-nucleoside reverse transcriptase inhibitor (NNRTI), such as efavirenz, is still the first-line treatment in resource-limited settings. However, efavirenz has shown strong prominence of disadvantages with variance in plasma concentration and central nervous side effects. Our study presents HIV infected, drug naïve, female patient with relatively low BMI, CYP2B6 516G>T (rs3745274) genotype with high efavirenz plasma concentration. In this case report, the patient was admitted at the hospital 6 months after cART initiation with drug-induced severe hepatotoxicity. Furthermore, pathophysiological findings proved confluent parenchymal necrosis after aspiration liver biopsy, with mild to moderate inflammation in portal tracts with focal interface hepatitis. All other possible causes were excluded. Thus, we conclude that efavirenz has a potential harmful effect in patients with low BMI, specific genotyping and interindividual pharmacokinetics affecting high plasma concentration." @default.
• W2977563485 created "2019-10-10" @default.
• W2977563485 creator A5006058276 @default.
• W2977563485 creator A5020765906 @default.
• W2977563485 creator A5029953471 @default.
• W2977563485 creator A5030700214 @default.
• W2977563485 creator A5064261065 @default.
• W2977563485 creator A5071484511 @default.
• W2977563485 creator A5085995049 @default.
• W2977563485 date "2019-09-03" @default.
• W2977563485 modified "2023-09-24" @default.
• W2977563485 title "Severe hepatotoxicity induced by efavirenz in a treatment-naïve, low body mass index HIV-infected, female patient with no hepatitis and other virus co-infections" @default.
• W2977563485 cites W1481716359 @default.
• W2977563485 cites W1549322092 @default.
• W2977563485 cites W2050330642 @default.
• W2977563485 cites W2071086973 @default.
• W2977563485 cites W2078584349 @default.
• W2977563485 cites W2095231520 @default.
• W2977563485 cites W2108243656 @default.
• W2977563485 cites W2108992076 @default.
• W2977563485 cites W2130874133 @default.
• W2977563485 cites W2135826395 @default.
• W2977563485 cites W2144467620 @default.
• W2977563485 cites W2163404084 @default.
• W2977563485 cites W2215039764 @default.
• W2977563485 cites W2322399034 @default.
• W2977563485 cites W2600224213 @default.
• W2977563485 cites W2806184984 @default.
• W2977563485 doi "https://doi.org/10.1080/01913123.2019.1673862" @default.
• W2977563485 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31578116" @default.
• W2977563485 hasPublicationYear "2019" @default.
• W2977563485 type Work @default.
• W2977563485 sameAs 2977563485 @default.
• W2977563485 citedByCount "4" @default.
• W2977563485 countsByYear W29775634852020 @default.
• W2977563485 countsByYear W29775634852021 @default.
• W2977563485 countsByYear W29775634852022 @default.
• W2977563485 crossrefType "journal-article" @default.
• W2977563485 hasAuthorship W2977563485A5006058276 @default.
• W2977563485 hasAuthorship W2977563485A5020765906 @default.
• W2977563485 hasAuthorship W2977563485A5029953471 @default.
• W2977563485 hasAuthorship W2977563485A5030700214 @default.
• W2977563485 hasAuthorship W2977563485A5064261065 @default.
• W2977563485 hasAuthorship W2977563485A5071484511 @default.
• W2977563485 hasAuthorship W2977563485A5085995049 @default.
• W2977563485 hasConcept C104317684 @default.
• W2977563485 hasConcept C112705442 @default.
• W2977563485 hasConcept C126322002 @default.
• W2977563485 hasConcept C127413603 @default.
• W2977563485 hasConcept C142462285 @default.
• W2977563485 hasConcept C156719811 @default.
• W2977563485 hasConcept C159047783 @default.
• W2977563485 hasConcept C203014093 @default.
• W2977563485 hasConcept C2522874641 @default.
• W2977563485 hasConcept C2775934546 @default.
• W2977563485 hasConcept C2776029263 @default.
• W2977563485 hasConcept C2777275308 @default.
• W2977563485 hasConcept C2777351918 @default.
• W2977563485 hasConcept C2777766500 @default.
• W2977563485 hasConcept C2781432083 @default.
• W2977563485 hasConcept C2909970146 @default.
• W2977563485 hasConcept C2993143319 @default.
• W2977563485 hasConcept C55493867 @default.
• W2977563485 hasConcept C67705224 @default.
• W2977563485 hasConcept C71924100 @default.
• W2977563485 hasConcept C78519656 @default.
• W2977563485 hasConcept C86803240 @default.
• W2977563485 hasConcept C90924648 @default.
• W2977563485 hasConcept C98274493 @default.
• W2977563485 hasConceptScore W2977563485C104317684 @default.
• W2977563485 hasConceptScore W2977563485C112705442 @default.
• W2977563485 hasConceptScore W2977563485C126322002 @default.
• W2977563485 hasConceptScore W2977563485C127413603 @default.
• W2977563485 hasConceptScore W2977563485C142462285 @default.
• W2977563485 hasConceptScore W2977563485C156719811 @default.
• W2977563485 hasConceptScore W2977563485C159047783 @default.
• W2977563485 hasConceptScore W2977563485C203014093 @default.
• W2977563485 hasConceptScore W2977563485C2522874641 @default.
• W2977563485 hasConceptScore W2977563485C2775934546 @default.
• W2977563485 hasConceptScore W2977563485C2776029263 @default.
• W2977563485 hasConceptScore W2977563485C2777275308 @default.
• W2977563485 hasConceptScore W2977563485C2777351918 @default.
• W2977563485 hasConceptScore W2977563485C2777766500 @default.
• W2977563485 hasConceptScore W2977563485C2781432083 @default.
• W2977563485 hasConceptScore W2977563485C2909970146 @default.
• W2977563485 hasConceptScore W2977563485C2993143319 @default.
• W2977563485 hasConceptScore W2977563485C55493867 @default.
• W2977563485 hasConceptScore W2977563485C67705224 @default.
• W2977563485 hasConceptScore W2977563485C71924100 @default.
• W2977563485 hasConceptScore W2977563485C78519656 @default.
• W2977563485 hasConceptScore W2977563485C86803240 @default.
• W2977563485 hasConceptScore W2977563485C90924648 @default.
• W2977563485 hasConceptScore W2977563485C98274493 @default.
• W2977563485 hasIssue "4-5" @default.
• W2977563485 hasLocation W29775634851 @default.
• W2977563485 hasLocation W29775634852 @default.
• W2977563485 hasOpenAccess W2977563485 @default.
• W2977563485 hasPrimaryLocation W29775634851 @default.

• next