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- W2977610533 endingPage "315" @default.
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- W2977610533 abstract "Mesenchymal stem cell transplantation is an emerging therapy for treating chronic liver diseases. The potential of this treatment has been evaluated in preclinical and clinical studies. Although the mechanisms of mesenchymal stem cell transplantation are still not completely understood, ac cumulating evidence has revealed that their immunomodula tion, differentiation, and antifibrotic properties play a crucial role in liver regeneration. The safety and therapeutic effects of mesenchymal stem cells in patients with chronic liver dis ease have been observed in many clinical studies. However, only modest improvements have been seen, partly because of the limited feasibility of transplanted cells at present. Here, we discuss several strategies targeted at improving vi able cell engraftment and the potential challenges in the use of extracellular vesicle-based therapies for liver disease in the future. (Gut Liver 2020;14:306-315)" @default.
- W2977610533 created "2019-10-10" @default.
- W2977610533 creator A5025716461 @default.
- W2977610533 creator A5055301233 @default.
- W2977610533 creator A5055410655 @default.
- W2977610533 creator A5056263474 @default.
- W2977610533 date "2020-05-15" @default.
- W2977610533 modified "2023-10-16" @default.
- W2977610533 title "Mesenchymal Stem Cells for the Treatment of Liver Disease: Present and Perspectives" @default.
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- W2977610533 doi "https://doi.org/10.5009/gnl18412" @default.
- W2977610533 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7234888" @default.