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• W2977611942 startingPage "20947" @default.
• W2977611942 abstract "Significance In human milk fat, saturated fatty acids are esterified to the middle position on the glycerol backbone giving the triacylglycerol molecules an unusual stereochemistry that assists nutrient absorption in the infant gut. However, the fat used in most infant formulas is derived from plants, which esterify saturated fatty acids to the outer positions. Here, we have engineered the metabolism of an oilseed plant so that it accumulates triacylglycerol with more than 70% of the saturated fatty acid palmitate in the middle position, thereby mimicking human milk fat stereoisomeric structure. Applying this technology to oilseed crops (or oleaginous microorganisms) might provide a source of human milk fat substitute for infant nutrition." @default.
• W2977611942 created "2019-10-10" @default.
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• W2977611942 date "2019-09-30" @default.
• W2977611942 modified "2023-10-02" @default.
• W2977611942 title "Engineering the stereoisomeric structure of seed oil to mimic human milk fat" @default.
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• W2977611942 doi "https://doi.org/10.1073/pnas.1907915116" @default.
• W2977611942 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6800330" @default.
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