FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2977647592> ?p ?o ?g. }

• W2977647592 endingPage "S232" @default.
• W2977647592 startingPage "S232" @default.
• W2977647592 abstract "Purpose: The purpose of this retrospective analysis was to determine if patients with gastroesophageal reflux disease (GERD) taking a twice-daily proton pump inhibitor (PPI) received more economical and successful management of their disease when switched to once-daily esomeprazole. Methods: Data were obtained from Integrated Healthcare Information Services (IHCIS). Adult patients (>18 years) with ≥1 ICD-9 diagnosis code foresophagitis, esophageal reflux, or heartburn were eligible for the analysis if they received a prescription for once-daily esomeprazole after receiving ≥3 months of prescriptions for a twice-daily PPI. Patients with a diagnosis indicating a hypersecretory condition or who received prior treatment with twice-daily esomeprazole or omeprazole 10 mg twice daily were excluded. Total costs for medical, inpatient, and pharmacy claims were included. The difference in total costs 6 months before and after conversion to once-daily esomeprazole were calculated and compared using Wilcoxon rank sum, Wilcoxon signed rank tests, and paired t-tests. A successful conversion was defined as one for which the patient remained on esomeprazole once daily without a dosage increase or a switch to another PPI. Results: Of 492,633 patients available from the IHCIS database, 595 met study criteria. Mean age was 50.3 ± 11.0 years; 60% were women; most common diagnoses were esophageal reflux (77%) or reflux esophagitis (53%); and patients were most commonly switched to once-daily esomeprazole from twice-daily lansoprazole 30 mg (36%) or omeprazole 20 mg (49%). Median per member per month (PMPM) savings were $36.72 for total costs (P = .0507) and $39.91 forpharmacy costs (P <.0001). Of the 595 patients, 430 (72%) achieved a “successful” conversion from a twice-daily PPI to once-daily esomeprazole. Median PMPM savings for successful conversions were $57.75 for total costs (P = .0254) and $54.73 for pharmacy costs (P <.0001). For failed conversions, the median PMPM additional costs were $42.42 (P = .4650) and $13.33 (P <= .0001) fortotal and pharmacy costs, respectively. Conclusions: Switching from a twice-daily PPI to once-daily esomeprazole had a high success rate and resulted in cost savings for payers. These findings demonstrate an effective means to manage GERD in patients who would otherwise incur higher costs while seeking an acceptable level of acid suppression." @default.
• W2977647592 created "2019-10-10" @default.
• W2977647592 creator A5014530928 @default.
• W2977647592 creator A5015946521 @default.
• W2977647592 creator A5050969739 @default.
• W2977647592 date "2004-10-01" @default.
• W2977647592 modified "2023-09-27" @default.
• W2977647592 title "RETROSPECTIVE COST ANALYSES OF SWITCHING FROM A TWICE-DAILY PROTON PUMP INHIBITOR TO ONCE-DAILY ESOMEPRAZOLE" @default.
• W2977647592 doi "https://doi.org/10.14309/00000434-200410001-00712" @default.
• W2977647592 hasPublicationYear "2004" @default.
• W2977647592 type Work @default.
• W2977647592 sameAs 2977647592 @default.
• W2977647592 citedByCount "1" @default.
• W2977647592 crossrefType "journal-article" @default.
• W2977647592 hasAuthorship W2977647592A5014530928 @default.
• W2977647592 hasAuthorship W2977647592A5015946521 @default.
• W2977647592 hasAuthorship W2977647592A5050969739 @default.
• W2977647592 hasConcept C126322002 @default.
• W2977647592 hasConcept C167135981 @default.
• W2977647592 hasConcept C2426938 @default.
• W2977647592 hasConcept C2776462128 @default.
• W2977647592 hasConcept C2777014526 @default.
• W2977647592 hasConcept C2777498785 @default.
• W2977647592 hasConcept C2778204628 @default.
• W2977647592 hasConcept C2778715759 @default.
• W2977647592 hasConcept C2779134260 @default.
• W2977647592 hasConcept C2781025758 @default.
• W2977647592 hasConcept C2909576783 @default.
• W2977647592 hasConcept C43270747 @default.
• W2977647592 hasConcept C71924100 @default.
• W2977647592 hasConcept C90924648 @default.
• W2977647592 hasConcept C98274493 @default.
• W2977647592 hasConceptScore W2977647592C126322002 @default.
• W2977647592 hasConceptScore W2977647592C167135981 @default.
• W2977647592 hasConceptScore W2977647592C2426938 @default.
• W2977647592 hasConceptScore W2977647592C2776462128 @default.
• W2977647592 hasConceptScore W2977647592C2777014526 @default.
• W2977647592 hasConceptScore W2977647592C2777498785 @default.
• W2977647592 hasConceptScore W2977647592C2778204628 @default.
• W2977647592 hasConceptScore W2977647592C2778715759 @default.
• W2977647592 hasConceptScore W2977647592C2779134260 @default.
• W2977647592 hasConceptScore W2977647592C2781025758 @default.
• W2977647592 hasConceptScore W2977647592C2909576783 @default.
• W2977647592 hasConceptScore W2977647592C43270747 @default.
• W2977647592 hasConceptScore W2977647592C71924100 @default.
• W2977647592 hasConceptScore W2977647592C90924648 @default.
• W2977647592 hasConceptScore W2977647592C98274493 @default.
• W2977647592 hasLocation W29776475921 @default.
• W2977647592 hasOpenAccess W2977647592 @default.
• W2977647592 hasPrimaryLocation W29776475921 @default.
• W2977647592 hasRelatedWork W1964789768 @default.
• W2977647592 hasRelatedWork W1968552480 @default.
• W2977647592 hasRelatedWork W1981949716 @default.
• W2977647592 hasRelatedWork W2024176002 @default.
• W2977647592 hasRelatedWork W2039710754 @default.
• W2977647592 hasRelatedWork W2082746732 @default.
• W2977647592 hasRelatedWork W2361165765 @default.
• W2977647592 hasRelatedWork W2372910640 @default.
• W2977647592 hasRelatedWork W2414580964 @default.
• W2977647592 hasRelatedWork W3139981236 @default.
• W2977647592 hasVolume "99" @default.
• W2977647592 isParatext "false" @default.
• W2977647592 isRetracted "false" @default.
• W2977647592 magId "2977647592" @default.
• W2977647592 workType "article" @default.