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- W2977649849 abstract "Abstract Sleep, a state of quiescence associated with growth and restorative processes, is conserved across species. Invertebrates including the nematode Caenorhabditis elegans exhibit sleep-like states during development and periods of satiety and stress. Here we describe two methods to study behavior and associated neural activity during sleep and awake states in adult C. elegans . A large microfluidic device facilitates population-wide assessment of long-term sleep behavior over 12 h, including effects of fluid flow, oxygen, feeding, odors, and genetic perturbations. Smaller devices allow simultaneous recording of sleep behavior and neuronal activity, and a closed-loop sleep detection system delivers chemical stimuli to individual animals to assess sleep-dependent changes to neural responses. Sleep increased the arousal threshold to aversive chemical stimulation, yet sensory neuron (ASH) and first-layer interneuron (AIB) responses were unchanged. This localizes adult sleep-dependent neuromodulation within interneurons presynaptic to the AVA premotor interneurons, rather than afferent sensory circuits." @default.
- W2977649849 created "2019-10-10" @default.
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- W2977649849 date "2019-10-03" @default.
- W2977649849 modified "2023-09-27" @default.
- W2977649849 title "Automated analysis of sleep in adultC. eleganswith closed-loop assessment of state-dependent neural activity" @default.
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- W2977649849 doi "https://doi.org/10.1101/791764" @default.
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