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- W2977674062 abstract "Objective To explore the changes of serum leptin level in patients with chronic heart failure (CHF) and the relationship between leptin and insulin resistance and hyperinsulinemia. Methods We studied leptin levels in 60 patients with CHF and 30 normal controls. The relation-ships between serum leptin level and insulin resistance and insulin concertration were also analyzed. Results Compared with the control group, CHF group had significantly increased serum leptin level(12.0±3.4)ng/mL vs (6.3±2.0) ng/mL, P 0.01, higher fasting insulin levels (24.1±5.5) mU/L vs (13.9±3.1) mU/L, P 0.01, and higher degree of insulin resistance (indicated by I-AI, 4.7±0.6 vs 4.1±0.8, P 0.01). Serum leptin level correlated with fasting insulin and IAI (r=0.832, P 0.01; r=0.755, P 0.01 respectively). Conclusions Serum leptin levels are increased in patients with CHF. There are positive relationship between serum leptin and insulin concentration and insulin resistance, indicating a possible role of insulin-leptin axis in the increased energy expenditure observed in patients with CHF." @default.
- W2977674062 created "2019-10-10" @default.
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- W2977674062 date "2004-01-01" @default.
- W2977674062 modified "2023-09-24" @default.
- W2977674062 title "Hyperleptinaemia and Its Relationships with Insulin Resistance in Patients with Chronic Heart Failure" @default.
- W2977674062 hasPublicationYear "2004" @default.
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