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- W2977736029 abstract "This work describes the development and validation of an ultra-high performance liquid chromatography tandem mass spectrometry method that uses disposable pipette extraction (DPX-UHPLC-MS/MS) to determine the endocannabinoid anandamide (AEA) in cerebrospinal fluid samples (CSF). The DPX parameters sorption equilibrium time, sample volume, number of draw-eject cycles, washing solvent volume, and elution solvent volume were optimized by design of experiments (DOE) techniques. The simple DPX protocol proposed herein required a reduced amount of CSF sample and organic solvent. The DPX-UHPLC-MS/MS method presented linear range from 0.10 ng mL−1 (LLOQ) to 3.0 ng mL−1, inter- and intra-assay accuracy with EPR values varying from −8.2% to 9.6%, inter- and intra-assay precision with CV values ranging from 1.3% to 14.8% (except for the LLOQ), and no significant matrix effect. The innovative DPX-UHPLC-MS/MS method was successfully applied to determine AEA in CSF samples from Parkinson’s disease (PD) patients and should therefore be used in clinical studies." @default.
- W2977736029 created "2019-10-10" @default.
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- W2977736029 date "2019-11-01" @default.
- W2977736029 modified "2023-09-30" @default.
- W2977736029 title "Determination of anandamide in cerebrospinal fluid samples by disposable pipette extraction and ultra-high performance liquid chromatography tandem mass spectrometry" @default.
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- W2977736029 doi "https://doi.org/10.1016/j.jchromb.2019.121809" @default.
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