FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2977770034> ?p ?o ?g. }

• W2977770034 endingPage "S124" @default.
• W2977770034 startingPage "S123" @default.
• W2977770034 abstract "Introduction: Improved life expectancy following the advent of anti-retroviral therapy (ART), has resulted in an increase in Non-AIDS Defining Cancers (NADCs) in patients with HIV. Published data are inconsistent on the prevalence of colorectal carcinoma (CRC) and outcomes of colon cancer screening in this cohort. Our aim was to evaluate the prevalence of colorectal neoplasms in HIV + patients undergoing screening colonoscopy and determine predictors of adenomas and CRC within this group. Methods: We performed a single-center retrospective cohort study of HIV + patients undergoing screening colonoscopy between 2012-2015. Known and hypothesized predictors of CRC and polyp characteristics were assessed (Table 1). Patients with a prior history of colon cancer or CRC screening, inflammatory bowel disease, inadequate or incomplete colonoscopy were excluded. Bivariate analyses were conducted to identify variables associated with colorectal neoplasms.Table 1: Patient Demographic and Clinical CharacteristicsResults: Our cohort of 168 patients had a mean age of 56.7 yrs (SD 5.2), was predominantly African American (86%) with 62% (104) men. 93% of patients were on ART and 45% had an undetectable HIV RNA. Baseline demographics are presented in Table 1. The prevalence of all adenomas was 27.4 % (46/168) and for advanced adenomas it was 6.6% (11/167). Colorectal cancer was detected in 3% of patients (5/167). CRC was detected in the sigmoid colon in 3, ascending colon in 1 and synchronous CRC in the ascending and sigmoid colon in 1 patient. Bivariate analysis of demographics and risk factors showed that CD4 count, history of ART, Hepatitis B or C status were not associated with adenoma amongst the HIV cohort. Age was significantly associated with CRC (p = 0.03) (Table 2). The mean age of patients with CRC was 61.8 years (SD: 5.9) years vs. 56.5 years (SD: 5.0) in patients without CRC.Table 2: Bivariate Analysis of Demographic/Clinical Predictors among HIV + Patients Undergoing Screening ColonoscopyConclusion: In our cohort, the overall prevalence of adenomas and advanced adenomas was comparable to the general population and above the thresholds for adenoma detection. Our cohort interestingly showed a notably higher rate of CRC (3%) compared to large, population-based screening colonoscopy studies (0.1-0.5%) and also other prior HIV cohorts, suggesting an increased risk in the HIV population during the ART era. This study reinforces the need for further research and refinement of colon cancer screening recommendations for individuals with HIV." @default.
• W2977770034 created "2019-10-10" @default.
• W2977770034 creator A5003221294 @default.
• W2977770034 creator A5013094847 @default.
• W2977770034 creator A5024102364 @default.
• W2977770034 creator A5024940610 @default.
• W2977770034 creator A5053093213 @default.
• W2977770034 creator A5075575064 @default.
• W2977770034 creator A5087525096 @default.
• W2977770034 date "2016-10-01" @default.
• W2977770034 modified "2023-09-27" @default.
• W2977770034 title "Increased Prevalence of Colorectal Carcinoma (CRC) in a HIV + Cohort: A Single-Center Retrospective Study" @default.
• W2977770034 doi "https://doi.org/10.14309/00000434-201610001-00265" @default.
• W2977770034 hasPublicationYear "2016" @default.
• W2977770034 type Work @default.
• W2977770034 sameAs 2977770034 @default.
• W2977770034 citedByCount "0" @default.
• W2977770034 crossrefType "journal-article" @default.
• W2977770034 hasAuthorship W2977770034A5003221294 @default.
• W2977770034 hasAuthorship W2977770034A5013094847 @default.
• W2977770034 hasAuthorship W2977770034A5024102364 @default.
• W2977770034 hasAuthorship W2977770034A5024940610 @default.
• W2977770034 hasAuthorship W2977770034A5053093213 @default.
• W2977770034 hasAuthorship W2977770034A5075575064 @default.
• W2977770034 hasAuthorship W2977770034A5087525096 @default.
• W2977770034 hasConcept C121608353 @default.
• W2977770034 hasConcept C126322002 @default.
• W2977770034 hasConcept C143998085 @default.
• W2977770034 hasConcept C167135981 @default.
• W2977770034 hasConcept C2776870353 @default.
• W2977770034 hasConcept C2778435480 @default.
• W2977770034 hasConcept C2780833581 @default.
• W2977770034 hasConcept C2781074409 @default.
• W2977770034 hasConcept C526805850 @default.
• W2977770034 hasConcept C71924100 @default.
• W2977770034 hasConcept C72563966 @default.
• W2977770034 hasConcept C90924648 @default.
• W2977770034 hasConceptScore W2977770034C121608353 @default.
• W2977770034 hasConceptScore W2977770034C126322002 @default.
• W2977770034 hasConceptScore W2977770034C143998085 @default.
• W2977770034 hasConceptScore W2977770034C167135981 @default.
• W2977770034 hasConceptScore W2977770034C2776870353 @default.
• W2977770034 hasConceptScore W2977770034C2778435480 @default.
• W2977770034 hasConceptScore W2977770034C2780833581 @default.
• W2977770034 hasConceptScore W2977770034C2781074409 @default.
• W2977770034 hasConceptScore W2977770034C526805850 @default.
• W2977770034 hasConceptScore W2977770034C71924100 @default.
• W2977770034 hasConceptScore W2977770034C72563966 @default.
• W2977770034 hasConceptScore W2977770034C90924648 @default.
• W2977770034 hasLocation W29777700341 @default.
• W2977770034 hasOpenAccess W2977770034 @default.
• W2977770034 hasPrimaryLocation W29777700341 @default.
• W2977770034 hasRelatedWork W1979672442 @default.
• W2977770034 hasRelatedWork W1981060974 @default.
• W2977770034 hasRelatedWork W1989918753 @default.
• W2977770034 hasRelatedWork W2029679167 @default.
• W2977770034 hasRelatedWork W2044658514 @default.
• W2977770034 hasRelatedWork W2091757794 @default.
• W2977770034 hasRelatedWork W2104003322 @default.
• W2977770034 hasRelatedWork W2907322099 @default.
• W2977770034 hasRelatedWork W2978262146 @default.
• W2977770034 hasRelatedWork W2978362450 @default.
• W2977770034 hasVolume "111" @default.
• W2977770034 isParatext "false" @default.
• W2977770034 isRetracted "false" @default.
• W2977770034 magId "2977770034" @default.
• W2977770034 workType "article" @default.