FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2977780983> ?p ?o ?g. }

• W2977780983 abstract "iNKT cells are CD1d-restricted T cells recognizing lipid antigens. The prototypic iNKT cell-agonist α-galactosylceramide (α-GalCer) alongside compounds with similar structures induces robust proliferation and cytokine production of iNKT cells and protects against cancer in vivo. Monoclonal antibodies (mAbs) that detect CD1d-α-GalCer complexes have provided critical information for understanding of antigen presentation of iNKT cell agonists. Although most iNKT cell agonists with antitumor properties are α-linked glycosphingolipids that can be detected by anti-CD1d-α-GalCer mAbs, β-ManCer, a glycolipid with a β-linkage, induces strong antitumor immunity via mechanisms distinct from those of α-GalCer. In this study, we unexpectedly discovered that anti-CD1d-α-GalCer mAbs directly recognized β-ManCer-CD1d complexes and could inhibit β-ManCer stimulation of iNKT cells. The binding of anti-CD1d-α-GalCer mAb with β-ManCer-CD1d complexes was also confirmed by plasmon resonance and could not be explained by α-anomer contamination. The binding of anti-CD1d-α-GalCer mAb was also observed with CD1d loaded with another β-linked glycosylceramide, β-GalCer (C26:0). Detection with anti-CD1d-α-GalCer mAbs indicates that the interface of the β-ManCer-CD1d complex exposed to the iNKT cell TCR can assume a structure like that of CD1d-α-GalCer, despite its disparate carbohydrate structure. These results suggest that certain β-linked monoglycosylceramides can assume a structural display similar to that of CD1d-α-GalCer and that the data based on anti-CD1d-α-GalCer binding should be interpreted with caution." @default.
• W2977780983 created "2019-10-10" @default.
• W2977780983 creator A5000254066 @default.
• W2977780983 creator A5003483056 @default.
• W2977780983 creator A5011700925 @default.
• W2977780983 creator A5016158429 @default.
• W2977780983 creator A5024024043 @default.
• W2977780983 creator A5035402521 @default.
• W2977780983 creator A5037677450 @default.
• W2977780983 creator A5047412668 @default.
• W2977780983 creator A5048766408 @default.
• W2977780983 creator A5056265030 @default.
• W2977780983 creator A5062001972 @default.
• W2977780983 creator A5062623647 @default.
• W2977780983 creator A5071664966 @default.
• W2977780983 creator A5082135173 @default.
• W2977780983 date "2019-10-09" @default.
• W2977780983 modified "2023-10-14" @default.
• W2977780983 title "Structure-Function Implications of the Ability of Monoclonal Antibodies Against α-Galactosylceramide-CD1d Complex to Recognize β-Mannosylceramide Presentation by CD1d" @default.
• W2977780983 cites W1483804182 @default.
• W2977780983 cites W1522913832 @default.
• W2977780983 cites W1524552658 @default.
• W2977780983 cites W1538172952 @default.
• W2977780983 cites W1553276030 @default.
• W2977780983 cites W1883217637 @default.
• W2977780983 cites W1968518932 @default.
• W2977780983 cites W1974208182 @default.
• W2977780983 cites W1974936220 @default.
• W2977780983 cites W2000059920 @default.
• W2977780983 cites W2004060523 @default.
• W2977780983 cites W2013660817 @default.
• W2977780983 cites W2024436717 @default.
• W2977780983 cites W2026578316 @default.
• W2977780983 cites W2037085755 @default.
• W2977780983 cites W2054082865 @default.
• W2977780983 cites W2059254962 @default.
• W2977780983 cites W2060237390 @default.
• W2977780983 cites W2067100150 @default.
• W2977780983 cites W2074059194 @default.
• W2977780983 cites W2086221611 @default.
• W2977780983 cites W2090580631 @default.
• W2977780983 cites W2090719316 @default.
• W2977780983 cites W2095433140 @default.
• W2977780983 cites W2096290400 @default.
• W2977780983 cites W2100495456 @default.
• W2977780983 cites W2103794578 @default.
• W2977780983 cites W2112413404 @default.
• W2977780983 cites W2116232985 @default.
• W2977780983 cites W2121477549 @default.
• W2977780983 cites W2136062652 @default.
• W2977780983 cites W2138567943 @default.
• W2977780983 cites W2140543815 @default.
• W2977780983 cites W2143220826 @default.
• W2977780983 cites W2151164793 @default.
• W2977780983 cites W2161307276 @default.
• W2977780983 cites W2170190208 @default.
• W2977780983 cites W2318334792 @default.
• W2977780983 cites W23696427 @default.
• W2977780983 cites W2595462418 @default.
• W2977780983 cites W33924759 @default.
• W2977780983 cites W4254839291 @default.
• W2977780983 doi "https://doi.org/10.3389/fimmu.2019.02355" @default.
• W2977780983 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6794452" @default.
• W2977780983 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31649670" @default.
• W2977780983 hasPublicationYear "2019" @default.
• W2977780983 type Work @default.
• W2977780983 sameAs 2977780983 @default.
• W2977780983 citedByCount "5" @default.
• W2977780983 countsByYear W29777809832020 @default.
• W2977780983 countsByYear W29777809832021 @default.
• W2977780983 countsByYear W29777809832022 @default.
• W2977780983 crossrefType "journal-article" @default.
• W2977780983 hasAuthorship W2977780983A5000254066 @default.
• W2977780983 hasAuthorship W2977780983A5003483056 @default.
• W2977780983 hasAuthorship W2977780983A5011700925 @default.
• W2977780983 hasAuthorship W2977780983A5016158429 @default.
• W2977780983 hasAuthorship W2977780983A5024024043 @default.
• W2977780983 hasAuthorship W2977780983A5035402521 @default.
• W2977780983 hasAuthorship W2977780983A5037677450 @default.
• W2977780983 hasAuthorship W2977780983A5047412668 @default.
• W2977780983 hasAuthorship W2977780983A5048766408 @default.
• W2977780983 hasAuthorship W2977780983A5056265030 @default.
• W2977780983 hasAuthorship W2977780983A5062001972 @default.
• W2977780983 hasAuthorship W2977780983A5062623647 @default.
• W2977780983 hasAuthorship W2977780983A5071664966 @default.
• W2977780983 hasAuthorship W2977780983A5082135173 @default.
• W2977780983 hasBestOaLocation W29777809831 @default.
• W2977780983 hasConcept C147483822 @default.
• W2977780983 hasConcept C159654299 @default.
• W2977780983 hasConcept C185592680 @default.
• W2977780983 hasConcept C19317047 @default.
• W2977780983 hasConcept C203014093 @default.
• W2977780983 hasConcept C2776090121 @default.
• W2977780983 hasConcept C2778607024 @default.
• W2977780983 hasConcept C542903549 @default.
• W2977780983 hasConcept C83464605 @default.
• W2977780983 hasConcept C86803240 @default.
• W2977780983 hasConcept C8891405 @default.
• W2977780983 hasConcept C95444343 @default.
• W2977780983 hasConceptScore W2977780983C147483822 @default.

• next