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- W2977787650 abstract "Introduction: Cancer screening and surgical improvement have increased steadily over recent years leading to improvement in the survival in most cancers. The aims of this study was to investigate the trend in the survival over time in patients with gallbladder carcinoma using a large population-based study. Methods: The Surveillance Epidemiology & End Results (SEER) Cancer registry was utilized to identify patients with histologically diagnosed gallbladder carcinoma between 2000 and 2013. Kaplan-Meier analysis was used to compare differences in carcinoma-specific survival between 2000-2007 and 2008-2013. Results: A total of 414 patients were identified for the study analysis, including 185 patients in 2000-2007 & 229 patients in 2008-2013. The mean age of the entire study cohort was 66.9 years (SEM: 0.632, range: 28-96), 80% white (10% black, 10% other) & 36% male. Staging was available in 174 (42%) pts, which demonstrated 8% in stage I, 36% in stage II, 53% in stage III & 3% in stage IV tumors. There was no significant difference in age, race, grade or localized/regional/distal extension between the time periods (all P>0.05). Treatment for the entire cohort included primary site surgery only (25%), radiation only (any form; 7.9%), surgery plus radiation (6.9%) or neither (60%). The proportion of patients undergoing treatment with either surgery or radiation was significantly different between the two study periods (P=0.011) with a 15% absolute increase in patients who did not undergo either surgery or radiation. Kaplan-Meier analysis revealed no significant differences in survival between 2000-2007 (6-month survival: 46%; 12-month survival: 34%) and 2008-2013 time periods (6-month survival: 48%; 12-month survival: 28%; log-rank: P=0.930) (figure 1). There were no significant differences in survival in last 13 years when every year was considered individually (all p>0.05).Figure 1Conclusion: There was no significant difference in the gallbladder carcinoma-specific survival in the last 13 years. Despite improvements in treatment strategies and surgical techniques, gallbladder carcinoma unfortunately continues to present with high mortality in patients afflicted with the disease." @default.
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- W2977787650 date "2016-10-01" @default.
- W2977787650 modified "2023-09-25" @default.
- W2977787650 title "Survival in Patients with Gallbladder Carcinoma over Last 13 Years: Are We Doing Any Better? A Population Based Study" @default.
- W2977787650 doi "https://doi.org/10.14309/00000434-201610001-00025" @default.
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