FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2977796624> ?p ?o ?g. }

• W2977796624 endingPage "S768" @default.
• W2977796624 startingPage "S768" @default.
• W2977796624 abstract "Introduction: IPAA is the standard therapy for ulcerative colitis (UC) patients requiring colectomy. Inflammatory and non-inflammatory complications of the ileal pouch are common. Serologic antimicrobial antibodies, such as pANCA, cBir1 or anti-glycan antibodies have been linked to pouchitis in IPAA subjects, but limited accuracy restricts their clinical use. Zymogen granule glycoprotein 2 (GP2) is the major autoantigen of CD-specific pancreatic autoantibodies. We tested two novel serologic anti-GP2 isoforms for association with pouch disorders in a cross-sectional analysis in IPAA patients. Methods: 157 serum samples of 143 consecutive and eligible pouch patients (mean age 43.6 +/- 13.4 years, 45.5% female) were obtained from the pouch clinic of a tertiary academic center. Serial samples were available for 13 subjects. Pouch disorders were diagnosed based on clinical, endoscopic, histologic and radiographic criteria. Presence of Anti-GP2 IgG and IgA Isoforms 1 & 4 was tested in serum samples using enzyme-linked immunosorbent assay (ELISA). Clinical data was recorded prospectively (pre-operative diagnosis, indication for colectomy, pouch type, pouch complications). Analysis was performed using Kruskal-Wallis, Pearson's chi square, Wilcoxon signed rank or Fisher's exact tests. Results: Median interval from construction of IPAA to sample procurement was 7.1 years (25th percentile 2.1; 75th percentile 13.2). 89.5% of participants had a J-pouch. Upon sample procurement, patient phenotypes included: normal pouch n=66, irritable pouch syndrome n=5, acute pouchitis n=17, refractory pouchitis n=24, CD of the pouch n=16, cuffitis n=30, other n=22. Presence of Anti-GP2 IgG Isoform 1 (p < 0.001) & 4 (p < 0.001) and Anti-GP2 IgA Isoform 1 (p=0.022) & 4 (p < 0.001) was associated with CD of the pouch. Presence of Anti-GP2 IgG Isoform 4 was linked to cuffitis (p=0.006). No marker was associated with pre-operative CD. Median interval time between serum procurement in IPAA subjects with serial samples was 3 months. There was no significant change in serum levels of Anti-GP2 antibodies over time. Conclusion: This study demonstrates a link between the two isoforms of Anti-GP2 antibodies with CD of the pouch in IPAA patients. Anti-GP2 was not associated with a pre-operative diagnosis of CD and anti-GP2 levels were stable over time. Serologic anti-GP2 antibodies could aid in diagnosis of CD of the pouch after IPAA." @default.
• W2977796624 created "2019-10-10" @default.
• W2977796624 creator A5012305407 @default.
• W2977796624 creator A5029863203 @default.
• W2977796624 creator A5056382724 @default.
• W2977796624 creator A5073007668 @default.
• W2977796624 creator A5082459823 @default.
• W2977796624 creator A5084707038 @default.
• W2977796624 date "2015-10-01" @default.
• W2977796624 modified "2023-10-18" @default.
• W2977796624 title "Serum Anti-GP2 Antibody Isoforms 1 and 4 Are associated With Crohnʼs Disease of the Pouch in Patients With Ileal-Pouch Anal Anastomosis (IPAA)" @default.
• W2977796624 doi "https://doi.org/10.14309/00000434-201510001-01807" @default.
• W2977796624 hasPublicationYear "2015" @default.
• W2977796624 type Work @default.
• W2977796624 sameAs 2977796624 @default.
• W2977796624 citedByCount "0" @default.
• W2977796624 crossrefType "journal-article" @default.
• W2977796624 hasAuthorship W2977796624A5012305407 @default.
• W2977796624 hasAuthorship W2977796624A5029863203 @default.
• W2977796624 hasAuthorship W2977796624A5056382724 @default.
• W2977796624 hasAuthorship W2977796624A5073007668 @default.
• W2977796624 hasAuthorship W2977796624A5082459823 @default.
• W2977796624 hasAuthorship W2977796624A5084707038 @default.
• W2977796624 hasConcept C126322002 @default.
• W2977796624 hasConcept C141071460 @default.
• W2977796624 hasConcept C2779134260 @default.
• W2977796624 hasConcept C2779454807 @default.
• W2977796624 hasConcept C2780101441 @default.
• W2977796624 hasConcept C2780479503 @default.
• W2977796624 hasConcept C71924100 @default.
• W2977796624 hasConcept C90924648 @default.
• W2977796624 hasConceptScore W2977796624C126322002 @default.
• W2977796624 hasConceptScore W2977796624C141071460 @default.
• W2977796624 hasConceptScore W2977796624C2779134260 @default.
• W2977796624 hasConceptScore W2977796624C2779454807 @default.
• W2977796624 hasConceptScore W2977796624C2780101441 @default.
• W2977796624 hasConceptScore W2977796624C2780479503 @default.
• W2977796624 hasConceptScore W2977796624C71924100 @default.
• W2977796624 hasConceptScore W2977796624C90924648 @default.
• W2977796624 hasLocation W29777966241 @default.
• W2977796624 hasOpenAccess W2977796624 @default.
• W2977796624 hasPrimaryLocation W29777966241 @default.
• W2977796624 hasRelatedWork W1968335745 @default.
• W2977796624 hasRelatedWork W1978869351 @default.
• W2977796624 hasRelatedWork W2002447517 @default.
• W2977796624 hasRelatedWork W2028875662 @default.
• W2977796624 hasRelatedWork W2042754372 @default.
• W2977796624 hasRelatedWork W2095948432 @default.
• W2977796624 hasRelatedWork W2316463897 @default.
• W2977796624 hasRelatedWork W2586562800 @default.
• W2977796624 hasRelatedWork W2789863584 @default.
• W2977796624 hasRelatedWork W4296163097 @default.
• W2977796624 hasVolume "110" @default.
• W2977796624 isParatext "false" @default.
• W2977796624 isRetracted "false" @default.
• W2977796624 magId "2977796624" @default.
• W2977796624 workType "article" @default.