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• W2977800324 abstract "Introduction: Diabetes (DM), a common micro and macrovascular disease has been increasing recognized as a risk factor for ischemic colitis (IC). However, the characteristics of IC in patients with DM are understudied. The aim of this study was to investigate patient characteristics in IC in DM patients & to identify any risk factors and outcomes. Methods: Medical records of patients with IC from 2007 to 2013 were reviewed. The study was conducted in two hospitals after IRB approval. Demographics, clinical/lab features, imaging, endoscopy, histology, co-morbidities, medication, surgery, length of hospital stay & death < 30 days of admission were collected. Patients were divided into IC with DM (DM-IC) & non-DM (non DM-IC) groups. The diagnosis of IC was based on clinical findings consistent IC & negative stool studies for infections & with at least one diagnostic study that was consistent with ischemic colitis (CT scan, colonoscopy, or histology). Exclusion criteria were age < 18, pregnancy, presence of enteric pathogens, colonic ischemia due to trauma or mechanical causes, chronic bowel ischemia, acute flare of inflammatory bowel disease, and radiological or colonoscopic evidence of diverticulitis. Results: A total of 117 pts with IC were identified (mean age 69.4 years, 83% females). A total of 25 (21.4%) DM compared to 92 (78.6%) non-DM with IC. DM-IC was disproportionately more prevalent in non-whites when compared to the whites (40% vs. 12%, p < 0.01). Use of NSAIDs was more common in DM-IC compared with non DM-IC Gp (20% vs 5.6%, p=0.02). Right sided colonic involvement was observed more in the DM-IC when compared with the non DM-IC (29.2% vs 11.5%, p=0.03). Histologically, mucosal hemorrhage (15.5% vs. 36.5%, p=0.03) and capillary thrombosis (2.8% vs. 13.6%, p=0.04) was more common in the DM-IC when compared to the non DM-IC. The clinical signs & symptoms, CT scan findings, endoscopic features, need for surgery, blood transfusion, ICU stay, mechanical ventilation, length of hospital stay, and mortality rates did not differ between the groups. Conclusion: Our study reports a strong association between DM and IC. Diabetics who are diagnosed with IC appear to be non-white, tend to have more right-sided colonic involvement, indicating a poor prognosis. This group more commonly uses NSAIDs and show hemorrhages and vessel thrombosis on histology. Our data could help healthcare professionals to carry out a more focused research in IC patients with DM." @default.
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• W2977800324 date "2015-10-01" @default.
• W2977800324 modified "2023-10-16" @default.
• W2977800324 title "Characteristics of Ischemic Colitis in Patients With Diabetes Mellitus" @default.
• W2977800324 doi "https://doi.org/10.14309/00000434-201510001-01314" @default.
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