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- W2977834103 abstract "The relationship between the ether chain length( EO number) in polysorbate 80 ingredients and hemolysis in vitro was investigated in this paper by using the production process of synthetic polysorbate 80. Using purified sorbitol,1,4-sorbitan and isosorbide as the starting material,etherified with different number of moles of oxirane. Then esterified with purified oleic acid.Sorbitol polyoxyethylene oleate( I),1,4-sorbitan polyoxyethylene oleate( II) and isosorbide polyoxyethylene oleate( III) with different ether chain length were synthesized. In the three ingredients,the molar ratio of the parent nucleus,ethylene oxide and oleic acid was1 ∶ n ∶ 1. 2,according to the molecular structure of the polysorbate 80( the n value was 42 ~ 12). The hemolysis in vitro test was made with the sample synthesized. Results show that three ingredients in polysorbate 80 were all hemolytic and the hemolysis was not only related to the structure of the parent nucleus,but also the length of the ether chain. The hemolytic rate was III > II ≈ I; Ether chain length on hemolysis has great influence,when the ether chain EO number greater than 40. Hemolysis of three ingredients is relatively low." @default.
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- W2977834103 date "2016-01-01" @default.
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- W2977834103 title "Study on Hemolysis of Polysorbate 80 Ingredients" @default.
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