FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2977881654> ?p ?o ?g. }

• W2977881654 abstract "Abstract Embryonic stem cell (ESC) derived tissue is a promising tool to be used in different clinical, preclinical and also scientific settings, for example as in vivo biological pacemaker, preclinical drug safety screening tool or ultimately as part of a cell replacement therapy. However, before ESC derived tissue can be used routinely for these purposes in humans, further studies are needed. In this context, the aims of the present study were to examine the effect of antiarrhythmic drugs on human ESC (hESC) und human induced pluripotent stem cell (hiPSC) derived cardiomyocytes by analyzing the beat rate variability (BRV), which can be considered as the in vitro equivalent of the heart rate variability (HRV) in vivo . Short-term recordings of extracellular field potentials of spontaneously beating cardiomyocytes derived from hESCs and hiPSCs were made using Microelectrode Arrays (MEA). The effect of Flecainide, Ivabradine and Metoprolol was tested. The offline analysis of the BRV was mainly focused on time domain methods. Additionally a non-linear analysis method was used. The evaluation of the Poincaré-Plots of the measurements without pharmacological intervention revealed that the vast majority of the scatter plots have a similar, ellipsoid shape. Flecainide and Ivabradine influenced BRV parameters significantly, whereas Metoprolol did not alter the BRV markedly. We detected remarkable similarities between the BRV of hESC and hiPSC derived cardiomyocytes in vitro and the HRV in vivo . The effect of antiarrhythmic drugs on spontaneously beating cardiomyocytes derived from hESC and hiPSC was generally consistent with clinical experiences and also with our previous study based on murine ESC derived cardiomyocytes. In conclusion, our study points out the great potential of hESC and hiPSC derived tissue to be used routinely for many different applications in medicine and science." @default.
• W2977881654 created "2019-10-10" @default.
• W2977881654 creator A5003778167 @default.
• W2977881654 creator A5035399483 @default.
• W2977881654 creator A5071484811 @default.
• W2977881654 creator A5083746732 @default.
• W2977881654 creator A5086802099 @default.
• W2977881654 date "2019-10-01" @default.
• W2977881654 modified "2023-09-25" @default.
• W2977881654 title "The Effect of Antiarrhythmic Drugs on the Beat Rate Variability of Human Embryonic and Human Induced Pluripotent Stem Cell Derived Cardiomyocytes" @default.
• W2977881654 cites W149528293 @default.
• W2977881654 cites W1530104121 @default.
• W2977881654 cites W1551495945 @default.
• W2977881654 cites W1583392605 @default.
• W2977881654 cites W1663797697 @default.
• W2977881654 cites W1964176079 @default.
• W2977881654 cites W1967900132 @default.
• W2977881654 cites W1970526294 @default.
• W2977881654 cites W1975968983 @default.
• W2977881654 cites W1976414968 @default.
• W2977881654 cites W1977529073 @default.
• W2977881654 cites W1986127144 @default.
• W2977881654 cites W1986371962 @default.
• W2977881654 cites W2014512584 @default.
• W2977881654 cites W2014699492 @default.
• W2977881654 cites W2030290211 @default.
• W2977881654 cites W2031383358 @default.
• W2977881654 cites W2033028174 @default.
• W2977881654 cites W2038625674 @default.
• W2977881654 cites W2039408416 @default.
• W2977881654 cites W2039712718 @default.
• W2977881654 cites W2045357781 @default.
• W2977881654 cites W2054017425 @default.
• W2977881654 cites W2066753241 @default.
• W2977881654 cites W2070481912 @default.
• W2977881654 cites W2082227074 @default.
• W2977881654 cites W2082953463 @default.
• W2977881654 cites W2086286954 @default.
• W2977881654 cites W2090369688 @default.
• W2977881654 cites W2098762794 @default.
• W2977881654 cites W2105571869 @default.
• W2977881654 cites W2113640125 @default.
• W2977881654 cites W2116002001 @default.
• W2977881654 cites W2122859962 @default.
• W2977881654 cites W2126025637 @default.
• W2977881654 cites W2128085444 @default.
• W2977881654 cites W2128242332 @default.
• W2977881654 cites W2133472982 @default.
• W2977881654 cites W2138442302 @default.
• W2977881654 cites W2142046859 @default.
• W2977881654 cites W2142492119 @default.
• W2977881654 cites W2155402169 @default.
• W2977881654 cites W2157723056 @default.
• W2977881654 cites W2161258444 @default.
• W2977881654 cites W2167741567 @default.
• W2977881654 cites W2258897683 @default.
• W2977881654 cites W2285072859 @default.
• W2977881654 cites W2331681079 @default.
• W2977881654 cites W2560528760 @default.
• W2977881654 cites W2582957437 @default.
• W2977881654 cites W2613096029 @default.
• W2977881654 cites W2893420171 @default.
• W2977881654 cites W4246928383 @default.
• W2977881654 doi "https://doi.org/10.1038/s41598-019-50557-7" @default.
• W2977881654 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6773847" @default.
• W2977881654 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31575920" @default.
• W2977881654 hasPublicationYear "2019" @default.
• W2977881654 type Work @default.
• W2977881654 sameAs 2977881654 @default.
• W2977881654 citedByCount "9" @default.
• W2977881654 countsByYear W29778816542020 @default.
• W2977881654 countsByYear W29778816542021 @default.
• W2977881654 countsByYear W29778816542022 @default.
• W2977881654 countsByYear W29778816542023 @default.
• W2977881654 crossrefType "journal-article" @default.
• W2977881654 hasAuthorship W2977881654A5003778167 @default.
• W2977881654 hasAuthorship W2977881654A5035399483 @default.
• W2977881654 hasAuthorship W2977881654A5071484811 @default.
• W2977881654 hasAuthorship W2977881654A5083746732 @default.
• W2977881654 hasAuthorship W2977881654A5086802099 @default.
• W2977881654 hasBestOaLocation W29778816541 @default.
• W2977881654 hasConcept C104317684 @default.
• W2977881654 hasConcept C107459253 @default.
• W2977881654 hasConcept C145103041 @default.
• W2977881654 hasConcept C150903083 @default.
• W2977881654 hasConcept C151730666 @default.
• W2977881654 hasConcept C164705383 @default.
• W2977881654 hasConcept C207001950 @default.
• W2977881654 hasConcept C2779161974 @default.
• W2977881654 hasConcept C2779343474 @default.
• W2977881654 hasConcept C2779837460 @default.
• W2977881654 hasConcept C2781280847 @default.
• W2977881654 hasConcept C55493867 @default.
• W2977881654 hasConcept C71924100 @default.
• W2977881654 hasConcept C86803240 @default.
• W2977881654 hasConcept C98274493 @default.
• W2977881654 hasConceptScore W2977881654C104317684 @default.
• W2977881654 hasConceptScore W2977881654C107459253 @default.
• W2977881654 hasConceptScore W2977881654C145103041 @default.
• W2977881654 hasConceptScore W2977881654C150903083 @default.

• next