Matches in SemOpenAlex for { <https://semopenalex.org/work/W2977887465> ?p ?o ?g. }
- W2977887465 endingPage "48.e4" @default.
- W2977887465 startingPage "34" @default.
- W2977887465 abstract "Impaired interhemispheric connectivity is commonly found in various psychiatric disorders, although how interhemispheric connectivity regulates brain function remains elusive. Here, we use the mouse amygdala, a brain region that is critical for social interaction and fear memory, as a model to demonstrate that contralateral connectivity intensifies the synaptic response of basolateral amygdalae (BLA) and regulates amygdala-dependent behaviors. Retrograde tracing and c-FOS expression indicate that contralateral afferents widely innervate BLA non-randomly and that some BLA neurons innervate both contralateral BLA and the ipsilateral central amygdala (CeA). Our optogenetic and electrophysiological studies further suggest that contralateral BLA input results in the synaptic facilitation of BLA neurons, thereby intensifying the responses to cortical and thalamic stimulations. Finally, pharmacological inhibition and chemogenetic disconnection demonstrate that BLA contralateral facilitation is required for social interaction and memory. Our study suggests that interhemispheric connectivity potentiates the synaptic dynamics of BLA neurons and is critical for the full activation and functionality of amygdalae." @default.
- W2977887465 created "2019-10-10" @default.
- W2977887465 creator A5001192688 @default.
- W2977887465 creator A5021301411 @default.
- W2977887465 creator A5021477044 @default.
- W2977887465 creator A5024081311 @default.
- W2977887465 creator A5027224164 @default.
- W2977887465 creator A5044035274 @default.
- W2977887465 creator A5055749746 @default.
- W2977887465 creator A5056699917 @default.
- W2977887465 creator A5074752529 @default.
- W2977887465 date "2019-10-01" @default.
- W2977887465 modified "2023-10-16" @default.
- W2977887465 title "Interhemispheric Connectivity Potentiates the Basolateral Amygdalae and Regulates Social Interaction and Memory" @default.
- W2977887465 cites W107231900 @default.
- W2977887465 cites W1547865271 @default.
- W2977887465 cites W1773498032 @default.
- W2977887465 cites W1834036377 @default.
- W2977887465 cites W1964444099 @default.
- W2977887465 cites W1965183327 @default.
- W2977887465 cites W1970612448 @default.
- W2977887465 cites W1977313055 @default.
- W2977887465 cites W1979877610 @default.
- W2977887465 cites W1980487320 @default.
- W2977887465 cites W1981890684 @default.
- W2977887465 cites W1982464932 @default.
- W2977887465 cites W1985482952 @default.
- W2977887465 cites W1986677428 @default.
- W2977887465 cites W1987895660 @default.
- W2977887465 cites W1988670106 @default.
- W2977887465 cites W1989982790 @default.
- W2977887465 cites W1990500865 @default.
- W2977887465 cites W1996642120 @default.
- W2977887465 cites W2002012536 @default.
- W2977887465 cites W2002537198 @default.
- W2977887465 cites W2003046304 @default.
- W2977887465 cites W2011150799 @default.
- W2977887465 cites W2013438045 @default.
- W2977887465 cites W2013896083 @default.
- W2977887465 cites W2015348290 @default.
- W2977887465 cites W2016532227 @default.
- W2977887465 cites W2024663595 @default.
- W2977887465 cites W2028819787 @default.
- W2977887465 cites W2029142963 @default.
- W2977887465 cites W2029245198 @default.
- W2977887465 cites W2030458571 @default.
- W2977887465 cites W2031248308 @default.
- W2977887465 cites W2052065200 @default.
- W2977887465 cites W2057607467 @default.
- W2977887465 cites W2058317952 @default.
- W2977887465 cites W2061637100 @default.
- W2977887465 cites W2072652550 @default.
- W2977887465 cites W2072739064 @default.
- W2977887465 cites W2074052814 @default.
- W2977887465 cites W2084179820 @default.
- W2977887465 cites W2084446158 @default.
- W2977887465 cites W2088944569 @default.
- W2977887465 cites W2090389523 @default.
- W2977887465 cites W2096114478 @default.
- W2977887465 cites W2108994842 @default.
- W2977887465 cites W2119714088 @default.
- W2977887465 cites W2132244902 @default.
- W2977887465 cites W2136309685 @default.
- W2977887465 cites W2137500715 @default.
- W2977887465 cites W2147829144 @default.
- W2977887465 cites W2150215597 @default.
- W2977887465 cites W2152331578 @default.
- W2977887465 cites W2153773863 @default.
- W2977887465 cites W2154205996 @default.
- W2977887465 cites W2154836288 @default.
- W2977887465 cites W2156366271 @default.
- W2977887465 cites W2156642993 @default.
- W2977887465 cites W2163027526 @default.
- W2977887465 cites W2168993339 @default.
- W2977887465 cites W2247835184 @default.
- W2977887465 cites W2286410651 @default.
- W2977887465 cites W2408769634 @default.
- W2977887465 cites W2537678584 @default.
- W2977887465 cites W2563595942 @default.
- W2977887465 cites W2565893752 @default.
- W2977887465 cites W2787829706 @default.
- W2977887465 cites W2922080893 @default.
- W2977887465 doi "https://doi.org/10.1016/j.celrep.2019.08.082" @default.
- W2977887465 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31577954" @default.
- W2977887465 hasPublicationYear "2019" @default.
- W2977887465 type Work @default.
- W2977887465 sameAs 2977887465 @default.
- W2977887465 citedByCount "13" @default.
- W2977887465 countsByYear W29778874652020 @default.
- W2977887465 countsByYear W29778874652021 @default.
- W2977887465 countsByYear W29778874652022 @default.
- W2977887465 countsByYear W29778874652023 @default.
- W2977887465 crossrefType "journal-article" @default.
- W2977887465 hasAuthorship W2977887465A5001192688 @default.
- W2977887465 hasAuthorship W2977887465A5021301411 @default.
- W2977887465 hasAuthorship W2977887465A5021477044 @default.
- W2977887465 hasAuthorship W2977887465A5024081311 @default.
- W2977887465 hasAuthorship W2977887465A5027224164 @default.