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- W2977889895 abstract "We characterized the landscape and drug sensitivity of ERBB2 (HER2) mutations in cancers. In 11 datasets (n = 211,726), ERBB2 mutational hotspots varied across 25 tumor types. Common HER2 mutants yielded differential sensitivities to eleven EGFR/HER2 tyrosine kinase inhibitors (TKIs) in vitro, and molecular dynamics simulations revealed that mutants with a reduced drug-binding pocket volume were associated with decreased affinity for larger TKIs. Overall, poziotinib was the most potent HER2 mutant-selective TKI tested. Phase II clinical testing in ERBB2 exon 20-mutant non-small cell lung cancer resulted in a confirmed objective response rate of 42% in the first 12 evaluable patients. In pre-clinical models, poziotinib upregulated HER2 cell-surface expression and potentiated the activity of T-DM1, resulting in complete tumor regression with combination treatment." @default.
- W2977889895 created "2019-10-10" @default.
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- W2977889895 date "2019-10-01" @default.
- W2977889895 modified "2023-10-17" @default.
- W2977889895 title "Pan-Cancer Landscape and Analysis of ERBB2 Mutations Identifies Poziotinib as a Clinically Active Inhibitor and Enhancer of T-DM1 Activity" @default.
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- W2977889895 cites W2067885064 @default.
- W2977889895 cites W2078304042 @default.
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- W2977889895 cites W2111578514 @default.
- W2977889895 cites W2115330997 @default.
- W2977889895 cites W2115339329 @default.
- W2977889895 cites W2130652363 @default.
- W2977889895 cites W2132437319 @default.
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- W2977889895 cites W2159013299 @default.
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- W2977889895 cites W2159967578 @default.
- W2977889895 cites W2161644181 @default.
- W2977889895 cites W2166199281 @default.
- W2977889895 cites W2175694606 @default.
- W2977889895 cites W2198093519 @default.
- W2977889895 cites W2404280981 @default.
- W2977889895 cites W2419594821 @default.
- W2977889895 cites W2471493685 @default.
- W2977889895 cites W2567564314 @default.
- W2977889895 cites W2590981502 @default.
- W2977889895 cites W2596393908 @default.
- W2977889895 cites W2598622710 @default.
- W2977889895 cites W2726739357 @default.
- W2977889895 cites W2735084022 @default.
- W2977889895 cites W2762777471 @default.
- W2977889895 cites W2770503852 @default.
- W2977889895 cites W2783112448 @default.
- W2977889895 cites W2785610956 @default.
- W2977889895 cites W2800224623 @default.
- W2977889895 cites W2801651204 @default.
- W2977889895 cites W2805369673 @default.
- W2977889895 cites W2806325305 @default.
- W2977889895 cites W2810059108 @default.
- W2977889895 cites W2885615830 @default.
- W2977889895 cites W2892176673 @default.
- W2977889895 cites W2892284712 @default.
- W2977889895 cites W2895175805 @default.
- W2977889895 cites W2901009857 @default.
- W2977889895 cites W2917696006 @default.