Matches in SemOpenAlex for { <https://semopenalex.org/work/W2977892534> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W2977892534 abstract "Objective To study the relative bioavailability and bioequivalence of tinidazole tablets (test) to the normal tablets (reference) in Chinese healthy volunteers. Methods Twenty male healthy volunteers were randomized to receive a single crossover oral dose of 1000 mg test tablets or reference tablets.The plasma concentration of tinidazole was determined by high-performance liquid chromatograply(HPLC). Results The method was linear in the 0.208～41.6 μg/ml concentration range(r=0.999 75);the mean recovery was 98.6%～99.6%;The inter-day sx and intra-day sx were less 10%.The main pharmacokinetic parameters without significant difference between test and reference tinidazole tablets were as follows:The inter-day sx and intra-day sx were less 10%;Tmax:(1.5±0.8) vs (1.5±1.3)h;Cmax:(20±3) vs (21±3)mg/L,AUC0~60 h:(390±55) vs (391±48)mg·L-1·h;AUC0~∞:(427±79) vs (424±59)mg·L-1·h;T1/2:(16.6±2.8)vs(16.1±1.9)h;F0~24 h was(100±6)%.The variance analysis and two-one sided t-test showed that there was no significant difference between the two formulations in the AUC and Cmax. Conclusion The assay is sensitive,accurate.The test tinidazole tablets is bioequivalent to the reference tablets." @default.
- W2977892534 created "2019-10-10" @default.
- W2977892534 creator A5070694205 @default.
- W2977892534 date "2005-01-01" @default.
- W2977892534 modified "2023-09-27" @default.
- W2977892534 title "Pharmacokinetics and bioequivalence study of tinidazole tablets in Chinese healthy volunteers" @default.
- W2977892534 hasPublicationYear "2005" @default.
- W2977892534 type Work @default.
- W2977892534 sameAs 2977892534 @default.
- W2977892534 citedByCount "0" @default.
- W2977892534 crossrefType "journal-article" @default.
- W2977892534 hasAuthorship W2977892534A5070694205 @default.
- W2977892534 hasConcept C112705442 @default.
- W2977892534 hasConcept C126322002 @default.
- W2977892534 hasConcept C142724271 @default.
- W2977892534 hasConcept C179998833 @default.
- W2977892534 hasConcept C181389837 @default.
- W2977892534 hasConcept C185592680 @default.
- W2977892534 hasConcept C204787440 @default.
- W2977892534 hasConcept C22979827 @default.
- W2977892534 hasConcept C27081682 @default.
- W2977892534 hasConcept C2777396551 @default.
- W2977892534 hasConcept C2780626017 @default.
- W2977892534 hasConcept C3018023364 @default.
- W2977892534 hasConcept C42404028 @default.
- W2977892534 hasConcept C43617362 @default.
- W2977892534 hasConcept C501593827 @default.
- W2977892534 hasConcept C55493867 @default.
- W2977892534 hasConcept C71924100 @default.
- W2977892534 hasConcept C87813604 @default.
- W2977892534 hasConcept C98274493 @default.
- W2977892534 hasConceptScore W2977892534C112705442 @default.
- W2977892534 hasConceptScore W2977892534C126322002 @default.
- W2977892534 hasConceptScore W2977892534C142724271 @default.
- W2977892534 hasConceptScore W2977892534C179998833 @default.
- W2977892534 hasConceptScore W2977892534C181389837 @default.
- W2977892534 hasConceptScore W2977892534C185592680 @default.
- W2977892534 hasConceptScore W2977892534C204787440 @default.
- W2977892534 hasConceptScore W2977892534C22979827 @default.
- W2977892534 hasConceptScore W2977892534C27081682 @default.
- W2977892534 hasConceptScore W2977892534C2777396551 @default.
- W2977892534 hasConceptScore W2977892534C2780626017 @default.
- W2977892534 hasConceptScore W2977892534C3018023364 @default.
- W2977892534 hasConceptScore W2977892534C42404028 @default.
- W2977892534 hasConceptScore W2977892534C43617362 @default.
- W2977892534 hasConceptScore W2977892534C501593827 @default.
- W2977892534 hasConceptScore W2977892534C55493867 @default.
- W2977892534 hasConceptScore W2977892534C71924100 @default.
- W2977892534 hasConceptScore W2977892534C87813604 @default.
- W2977892534 hasConceptScore W2977892534C98274493 @default.
- W2977892534 hasLocation W29778925341 @default.
- W2977892534 hasOpenAccess W2977892534 @default.
- W2977892534 hasPrimaryLocation W29778925341 @default.
- W2977892534 hasRelatedWork W2349594683 @default.
- W2977892534 hasRelatedWork W2354173935 @default.
- W2977892534 hasRelatedWork W2354527363 @default.
- W2977892534 hasRelatedWork W2359991048 @default.
- W2977892534 hasRelatedWork W2360021391 @default.
- W2977892534 hasRelatedWork W2364425864 @default.
- W2977892534 hasRelatedWork W2367076873 @default.
- W2977892534 hasRelatedWork W2367703786 @default.
- W2977892534 hasRelatedWork W2374276485 @default.
- W2977892534 hasRelatedWork W2382979737 @default.
- W2977892534 hasRelatedWork W2383865603 @default.
- W2977892534 hasRelatedWork W2385864291 @default.
- W2977892534 hasRelatedWork W2387130355 @default.
- W2977892534 hasRelatedWork W2387179868 @default.
- W2977892534 hasRelatedWork W2387348810 @default.
- W2977892534 hasRelatedWork W2387850616 @default.
- W2977892534 hasRelatedWork W2388529912 @default.
- W2977892534 hasRelatedWork W2389625094 @default.
- W2977892534 hasRelatedWork W2809704462 @default.
- W2977892534 hasRelatedWork W2182970403 @default.
- W2977892534 isParatext "false" @default.
- W2977892534 isRetracted "false" @default.
- W2977892534 magId "2977892534" @default.
- W2977892534 workType "article" @default.