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• W2977893210 abstract "Introduction: Eosinophilic Esophagitis (EoE) is a chronic, immune mediated disorder of the esophagus characterized by mucosal eosinophilic infiltration. Topical Glucocorticoids are considered standard line of treatment while endoscopic dilations are performed for patients presenting with treatment resistant disease or manifestations of dysphagia and/or food impactions. Efficacy of esophageal dilation in these patients is currently unclear. Aims: Primary outcome was to evaluate the efficacy of endoscopic esophageal dilation in patients with EoE. Methods: Study Selection Criterion: Studies that reported the use of esophageal dilation in EoE patients were included in this meta-analysis. Data collection and extraction: Articles were searched in Medline, Pubmed, and Ovid journals. Two authors independently searched and extracted data. The study design was written in accordance to PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) statement. Clinical improvement was defined as patient reported symptom relief noted by the authors of individual studies. The symptoms were assessed on various non-standardized, however relevant questionnaires that were deemed appropriate by the senior authors of individual studies. Statistical Methods: Pooled proportions were calculated using fixed and random effects model. The heterogeneity among studies was tested using I2 statistic. Results: Results: Initial search identified 491 reference articles, in which 39 articles were selected and reviewed. Data was extracted from 14 studies (N=1607) using esophageal dilation for EoE management, which met the inclusion criterion. Among the 1607 patients with a confirmed diagnosis of EoE, 809 patients underwent esophageal dilation at least one time. Total number of dilation procedures was 1543. Median number of dilations per patient was two. One of the three techniques (savary, Maloney and through the scope balloon) was used to perform dilation. Mean age of patients was 41years. Pooled patients included 75% males. The pooled proportion of patients that showed clinical improvement with esophageal dilations, after the median follow up period of 12 months was 84.95% (95% CI = 81.72 to 87.93). I2 (inconsistency) was 91% (95% CI = 85.6 to 93.7%) and Egger: bias was -3.3 (95% CI = -6.52 to -0.02). Conclusion: Conclusions: In patients with conformed diagnosis of EoE, endoscopic esophageal dilation seems to be an effective treatment option to achieve clinical improvement." @default.
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• W2977893210 date "2016-10-01" @default.
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• W2977893210 title "Clinical Improvement in Eosinophilic Esophagitis Patients Treated with Endoscopic Esophageal Dilation: A Meta-analysis and Systematic Review" @default.
• W2977893210 doi "https://doi.org/10.14309/00000434-201610001-00517" @default.
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