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- W2977908669 abstract "Abstract The release of acetylcholine (ACh) by substance P (SP) from the guinea pig ileum was studied. The ACh released from the longitudinal muscle strip with myenteric plexus (LMP strip) was collected in the presence of physostigmine (5uM) and choline (luM) at 37°C. SP produced a rapid contraction of LMP strip followed by a slow decline which stayed at a plateau level above the baseline. This remaining contraction was abolished by tetrodotoxin (TTX). SP (300-3000nM) enhanced the resting ACh release from the LMP strips. The ACh release was maintained during the presence of SP (300nM) and only slowly declined even at a higher concentration (3000nM), suggesting that SP receptors in the myenteric plexus are less readily desensitized by SP than those located on the smooth muscle. The effect of SP on the ACh release was completely or strongly inhibited by TTX, morphine or removal of Ca2+ from the medium and partially inhibited by hexamethonium (500uM) or methysergide (28uM) although the preparations desensitized to nicotine or 5-hydroxytryptamine were still sensitive to SP. SP enhanced the ACh release induced by radial distention of the intestinal wall in the dosage (30nM) which did not stimulate the resting ACh release per se. The release induced by nicotine or electrical stimulation, however, were not affected. These data suggest that SP acts as a neurotransmitter or a neuromodulator through the SP receptor in the myenteric plexus which can increase the ACh release in addition to its musculotropic effect." @default.
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- W2977908669 date "1983-01-01" @default.
- W2977908669 modified "2023-09-24" @default.
- W2977908669 title "The effect of substance P on the acetylcholine release from the guinea-pig ileum" @default.
- W2977908669 doi "https://doi.org/10.1016/s0021-5198(19)60411-7" @default.
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