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- W2977922016 abstract "Fetal goitre may occur in the setting of fetal hypothyroidism, and less frequently with hyperthyroidism or euthyroidism. Complications can occur due to oesophageal and tracheal obstruction, and high output cardiac failure. Identification and appropriate management is imperative for optimum fetal development. We present a case series of 3 cases of antenatally diagnosed fetal goitre and hypothyroidism confirmed by cordocentesis and treated with intra-amniotic instillation of dissolved levothyroxine tablet. All three cases presented with polyhydramnios between 26-29 weeks of gestation. Ultrasound examination revealed enlarged fetal thyroid with increased vascularity along with polyhydramnios. Cord blood TSH was found to be very high with low free triiodothyronine (FT3) and free thyroxine (FT4) levels. Since injectable thyroxine was not available in India, intraamniotic instillation of levothyroxine tablet (10µg/kg of estimated fetal weight/day) for 7 day dose, was dissolved in aspirated amniotic fluid and instilled back. Serial instillation resulted in decreased thyroid volume and liquor. All three pregnancies ended between 36-37 weeks of gestation. All the babies are on thyroid replacement therapy on follow up with normal milestones. Tablet levothyroxine can be instilled into amniotic fluid after dissolving it in aspirated amniotic fluid to treat fetal hypothyroidism associated goitre. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article." @default.
- W2977922016 created "2019-10-10" @default.
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- W2977922016 date "2019-09-30" @default.
- W2977922016 modified "2023-09-27" @default.
- W2977922016 title "EP24.08: Management of fetal goitre due to hypothyroidism by levothyroxine tablet installation into amniotic fluid" @default.
- W2977922016 doi "https://doi.org/10.1002/uog.21635" @default.
- W2977922016 hasPublicationYear "2019" @default.
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