Matches in SemOpenAlex for { <https://semopenalex.org/work/W2977928131> ?p ?o ?g. }
- W2977928131 endingPage "101304" @default.
- W2977928131 startingPage "101304" @default.
- W2977928131 abstract "Abstract This study aims to formulate a nanosystem of ofloxacin (OFLOX) for nose-to-brain delivery to enhance brain accumulation and improve management of bacterial meningitis. OFLOX loaded transfersomal nanovesicles (OFLOX-TNVs) were prepared by a thin film hydration technique. A Box-Behnken design was employed to investigate the influence of Lipid concentration, Edge Activator concentration, and Cholesterol amount on particle size, entrapment efficiency, and intranasal permeation. Lipid concentration of 5% w/v and edge activator concentration of 14.6% w/w without cholesterol produced 271.5 nm particles entrapping 79.3% of the total drug added. Percentage of OFLOX released from the optimized nanovesicles was 75.39%, and 78.7% of the drug permeated after 24 h. Histopathological investigation displayed that the optimal formula in an in situ gel is tolerable. Pharmacokinetic study showed that the brain blood ratios of OFLOX from intravenous solution, intranasal solution, and intranasal OFLOX-TNVs in an in situ gel were 0.305, 0.579, and 1.858 respectively at 30 min. It is concluded that nanotransfersomes loaded with OFLOX could be a promising colloidal drug delivery system for effective brain targeting and treatment of bacterial meningitis. However, preclinical and clinical investigations are essential to evaluate its efficacy in humans." @default.
- W2977928131 created "2019-10-10" @default.
- W2977928131 creator A5016077008 @default.
- W2977928131 creator A5018571901 @default.
- W2977928131 creator A5049521775 @default.
- W2977928131 creator A5069139450 @default.
- W2977928131 date "2019-12-01" @default.
- W2977928131 modified "2023-10-01" @default.
- W2977928131 title "Transfersomal nanovesicles for nose-to-brain delivery of ofloxacin for better management of bacterial meningitis: Formulation, optimization by Box-Behnken design, characterization and in vivo pharmacokinetic study" @default.
- W2977928131 cites W1655473723 @default.
- W2977928131 cites W1867319330 @default.
- W2977928131 cites W1966433192 @default.
- W2977928131 cites W1980036775 @default.
- W2977928131 cites W1980130336 @default.
- W2977928131 cites W1982144004 @default.
- W2977928131 cites W1988635349 @default.
- W2977928131 cites W1999021486 @default.
- W2977928131 cites W2001698270 @default.
- W2977928131 cites W2005568225 @default.
- W2977928131 cites W2008213465 @default.
- W2977928131 cites W2014325374 @default.
- W2977928131 cites W2019083828 @default.
- W2977928131 cites W2021500752 @default.
- W2977928131 cites W2022307082 @default.
- W2977928131 cites W2024363028 @default.
- W2977928131 cites W2042253399 @default.
- W2977928131 cites W2052254665 @default.
- W2977928131 cites W2054872615 @default.
- W2977928131 cites W2058719755 @default.
- W2977928131 cites W2072692763 @default.
- W2977928131 cites W2073547374 @default.
- W2977928131 cites W2082599309 @default.
- W2977928131 cites W2086889742 @default.
- W2977928131 cites W2091322268 @default.
- W2977928131 cites W2093918270 @default.
- W2977928131 cites W2094852979 @default.
- W2977928131 cites W2102109292 @default.
- W2977928131 cites W2109709772 @default.
- W2977928131 cites W2125352668 @default.
- W2977928131 cites W2125759360 @default.
- W2977928131 cites W2147699276 @default.
- W2977928131 cites W2150401281 @default.
- W2977928131 cites W2166458266 @default.
- W2977928131 cites W2168089247 @default.
- W2977928131 cites W2171132700 @default.
- W2977928131 cites W2341645506 @default.
- W2977928131 cites W2558522085 @default.
- W2977928131 cites W2613111799 @default.
- W2977928131 cites W2770491550 @default.
- W2977928131 cites W2908110420 @default.
- W2977928131 doi "https://doi.org/10.1016/j.jddst.2019.101304" @default.
- W2977928131 hasPublicationYear "2019" @default.
- W2977928131 type Work @default.
- W2977928131 sameAs 2977928131 @default.
- W2977928131 citedByCount "19" @default.
- W2977928131 countsByYear W29779281312020 @default.
- W2977928131 countsByYear W29779281312021 @default.
- W2977928131 countsByYear W29779281312022 @default.
- W2977928131 countsByYear W29779281312023 @default.
- W2977928131 crossrefType "journal-article" @default.
- W2977928131 hasAuthorship W2977928131A5016077008 @default.
- W2977928131 hasAuthorship W2977928131A5018571901 @default.
- W2977928131 hasAuthorship W2977928131A5049521775 @default.
- W2977928131 hasAuthorship W2977928131A5069139450 @default.
- W2977928131 hasConcept C112705442 @default.
- W2977928131 hasConcept C150077022 @default.
- W2977928131 hasConcept C150903083 @default.
- W2977928131 hasConcept C170295934 @default.
- W2977928131 hasConcept C185592680 @default.
- W2977928131 hasConcept C192562407 @default.
- W2977928131 hasConcept C207001950 @default.
- W2977928131 hasConcept C2778049240 @default.
- W2977928131 hasConcept C2778512257 @default.
- W2977928131 hasConcept C43617362 @default.
- W2977928131 hasConcept C501593827 @default.
- W2977928131 hasConcept C71924100 @default.
- W2977928131 hasConcept C85663871 @default.
- W2977928131 hasConcept C86803240 @default.
- W2977928131 hasConcept C89423630 @default.
- W2977928131 hasConcept C98274493 @default.
- W2977928131 hasConceptScore W2977928131C112705442 @default.
- W2977928131 hasConceptScore W2977928131C150077022 @default.
- W2977928131 hasConceptScore W2977928131C150903083 @default.
- W2977928131 hasConceptScore W2977928131C170295934 @default.
- W2977928131 hasConceptScore W2977928131C185592680 @default.
- W2977928131 hasConceptScore W2977928131C192562407 @default.
- W2977928131 hasConceptScore W2977928131C207001950 @default.
- W2977928131 hasConceptScore W2977928131C2778049240 @default.
- W2977928131 hasConceptScore W2977928131C2778512257 @default.
- W2977928131 hasConceptScore W2977928131C43617362 @default.
- W2977928131 hasConceptScore W2977928131C501593827 @default.
- W2977928131 hasConceptScore W2977928131C71924100 @default.
- W2977928131 hasConceptScore W2977928131C85663871 @default.
- W2977928131 hasConceptScore W2977928131C86803240 @default.
- W2977928131 hasConceptScore W2977928131C89423630 @default.
- W2977928131 hasConceptScore W2977928131C98274493 @default.
- W2977928131 hasLocation W29779281311 @default.
- W2977928131 hasOpenAccess W2977928131 @default.