Matches in SemOpenAlex for { <https://semopenalex.org/work/W2977952989> ?p ?o ?g. }
- W2977952989 endingPage "1866" @default.
- W2977952989 startingPage "1857" @default.
- W2977952989 abstract "Three new 5-deoxyflavonoid and dihydroflavonoids 2, 3 and 4 have been isolated from the methanolic extract of Abutioln pakistanicum aerial parts, for which structures were elucidated explicitly by extensive MS- and NMR-experiments. In addition to these, 3,7,4′-trihydroxy-3′-methoxy flavonol (1) is reported for the first time from Abutioln pakistanicum. Compound 2 and 4 are p-coumaric acid esters while compounds 2–4 exhibited α-glucosidase inhibitory activity. Docking studies indicated that the ability of flavonoids 2, 3 and 4 to form multiple hydrogen bonds with catalytically important residues is decisive hence is responsible for the inhibition activity. The docking results signified the observed in-vitro activity quite well which is in accordance with previously obtained conclusion that phenol moiety and hydroxyl group are critical for the inhibition of α-glucosidase enzyme." @default.
- W2977952989 created "2019-10-10" @default.
- W2977952989 creator A5000170064 @default.
- W2977952989 creator A5009621733 @default.
- W2977952989 creator A5024912700 @default.
- W2977952989 creator A5053861395 @default.
- W2977952989 creator A5054368569 @default.
- W2977952989 creator A5062086684 @default.
- W2977952989 creator A5064723726 @default.
- W2977952989 creator A5071433290 @default.
- W2977952989 creator A5079628101 @default.
- W2977952989 creator A5083606804 @default.
- W2977952989 creator A5089593640 @default.
- W2977952989 date "2019-11-02" @default.
- W2977952989 modified "2023-10-18" @default.
- W2977952989 title "α-Glucosidase Inhibition and Docking Studies of 5-Deoxyflavonols and Dihydroflavonols Isolated from Abutilon pakistanicum" @default.
- W2977952989 cites W1985475664 @default.
- W2977952989 cites W2016403352 @default.
- W2977952989 cites W2033862048 @default.
- W2977952989 cites W2038639877 @default.
- W2977952989 cites W2041504287 @default.
- W2977952989 cites W2043901865 @default.
- W2977952989 cites W2062388527 @default.
- W2977952989 cites W2068293231 @default.
- W2977952989 cites W2070915968 @default.
- W2977952989 cites W2087042387 @default.
- W2977952989 cites W2104566862 @default.
- W2977952989 cites W2126891950 @default.
- W2977952989 cites W2152301430 @default.
- W2977952989 cites W2181218334 @default.
- W2977952989 cites W2325326010 @default.
- W2977952989 cites W250643896 @default.
- W2977952989 cites W815731076 @default.
- W2977952989 doi "https://doi.org/10.2174/1385272823666191001224741" @default.
- W2977952989 hasPublicationYear "2019" @default.
- W2977952989 type Work @default.
- W2977952989 sameAs 2977952989 @default.
- W2977952989 citedByCount "1" @default.
- W2977952989 countsByYear W29779529892022 @default.
- W2977952989 crossrefType "journal-article" @default.
- W2977952989 hasAuthorship W2977952989A5000170064 @default.
- W2977952989 hasAuthorship W2977952989A5009621733 @default.
- W2977952989 hasAuthorship W2977952989A5024912700 @default.
- W2977952989 hasAuthorship W2977952989A5053861395 @default.
- W2977952989 hasAuthorship W2977952989A5054368569 @default.
- W2977952989 hasAuthorship W2977952989A5062086684 @default.
- W2977952989 hasAuthorship W2977952989A5064723726 @default.
- W2977952989 hasAuthorship W2977952989A5071433290 @default.
- W2977952989 hasAuthorship W2977952989A5079628101 @default.
- W2977952989 hasAuthorship W2977952989A5083606804 @default.
- W2977952989 hasAuthorship W2977952989A5089593640 @default.
- W2977952989 hasConcept C112887158 @default.
- W2977952989 hasConcept C159110408 @default.
- W2977952989 hasConcept C178790620 @default.
- W2977952989 hasConcept C181199279 @default.
- W2977952989 hasConcept C185592680 @default.
- W2977952989 hasConcept C2776568683 @default.
- W2977952989 hasConcept C2777702071 @default.
- W2977952989 hasConcept C2778247072 @default.
- W2977952989 hasConcept C2780213334 @default.
- W2977952989 hasConcept C32909587 @default.
- W2977952989 hasConcept C41685203 @default.
- W2977952989 hasConcept C55493867 @default.
- W2977952989 hasConcept C71240020 @default.
- W2977952989 hasConcept C71924100 @default.
- W2977952989 hasConceptScore W2977952989C112887158 @default.
- W2977952989 hasConceptScore W2977952989C159110408 @default.
- W2977952989 hasConceptScore W2977952989C178790620 @default.
- W2977952989 hasConceptScore W2977952989C181199279 @default.
- W2977952989 hasConceptScore W2977952989C185592680 @default.
- W2977952989 hasConceptScore W2977952989C2776568683 @default.
- W2977952989 hasConceptScore W2977952989C2777702071 @default.
- W2977952989 hasConceptScore W2977952989C2778247072 @default.
- W2977952989 hasConceptScore W2977952989C2780213334 @default.
- W2977952989 hasConceptScore W2977952989C32909587 @default.
- W2977952989 hasConceptScore W2977952989C41685203 @default.
- W2977952989 hasConceptScore W2977952989C55493867 @default.
- W2977952989 hasConceptScore W2977952989C71240020 @default.
- W2977952989 hasConceptScore W2977952989C71924100 @default.
- W2977952989 hasFunder F4320321709 @default.
- W2977952989 hasFunder F4320322780 @default.
- W2977952989 hasIssue "17" @default.
- W2977952989 hasLocation W29779529891 @default.
- W2977952989 hasOpenAccess W2977952989 @default.
- W2977952989 hasPrimaryLocation W29779529891 @default.
- W2977952989 hasRelatedWork W1804425206 @default.
- W2977952989 hasRelatedWork W1966534378 @default.
- W2977952989 hasRelatedWork W1981363320 @default.
- W2977952989 hasRelatedWork W1995545479 @default.
- W2977952989 hasRelatedWork W2045060966 @default.
- W2977952989 hasRelatedWork W2057931667 @default.
- W2977952989 hasRelatedWork W2069211232 @default.
- W2977952989 hasRelatedWork W2107855978 @default.
- W2977952989 hasRelatedWork W2218170419 @default.
- W2977952989 hasRelatedWork W4281692041 @default.
- W2977952989 hasVolume "23" @default.
- W2977952989 isParatext "false" @default.
- W2977952989 isRetracted "false" @default.