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- W2977962616 abstract "Objective:To establish a multi drug resistant cell line derived from highly metastatic human salivary gland mucoepidermoid carcinoma cell line MC3.Methods:MC3 cells were injected into athymic mice and the mice were given 5-FU by intraperitoneal injection.After in vivo induction the tumor cells were in vitro cultured and exposed to 5-FU at a constant concentration regularly.The 5-FU induced cells were named MC3/5-FU.The characteristic of MC3/5-FU was studied with MTT assay,flowcytometry and transmission electron microscopy.The expression of MDR-1 gene was examined by RT-PCR.Results:The morphology of MC3 and MC3/5-FU cells were not obviously different.The population doubling time of MC3/5-FU and MC3 was 55 h and 60 h respectively.The resistance index of MC3/5-FU cells to 5-FU,BLM,VCR,VBL and CDDP were 13.3,4.2,6.5,6.9 and 0.7 respectively.PCR electrophoresis assay showed that expression of MDR-1 gene was higher in MC3/5-FU cells than in MC3.MC3/5-FU was P-gp positive while MC3 was negative.Conclusion:MC3/5-FU is a multi drug resistant cell line." @default.
- W2977962616 created "2019-10-10" @default.
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- W2977962616 date "2009-01-01" @default.
- W2977962616 modified "2023-09-26" @default.
- W2977962616 title "Establishment and characterization of a multi drug resistant cell line derived from highly metastatic human salivary gland mucoepidermoid carcinoma cell line MC3" @default.
- W2977962616 hasPublicationYear "2009" @default.
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