FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2977997680> ?p ?o ?g. }

• W2977997680 endingPage "S928" @default.
• W2977997680 startingPage "S928" @default.
• W2977997680 abstract "Introduction: The clinical significance of sucrase deficiency (SD) in children and adults with gastrointestinal (GI) symptoms has not been well-characterized. SD has only recently been recognized to be more prevalent in the general population due to compound heterozygosity. This retrospective study assessed the clinical characteristics of pediatric patients found to have SD from small intestinal biopsies assayed for disaccharidases in a large cohort of patients during EGD. Methods: Endoscopic records of patients undergoing EGD over a 5-year period (2010-2015) at a freestanding endoscopy center serving 13 pediatric gastroenterologists were reviewed. The records of patients with SD were further analyzed to characterize their clinical characteristics and treatment outcomes. Results: Among 5,362 patients undergoing EGD, disaccharidase testing was performed in 963 (18%) at physician discretion. Of these, 73 (7.6%) were SD ( < 25 μmol/min/gm). Most had SD in combination with lactase deficiency (LD) (n=25; 34%) or pan-disaccharidase (n=44; 60%) deficiency with only four (5%) having isolated SD; age was 12.0±4.6 years and 45 (61.6%) were male. Most had abdominal pain (49; 78%) and/or diarrhea (27; 43%) although constipation, nausea, vomiting, weight loss/FTT, flatulence and bloating were not uncommon. Abnormal biopsies were found in 33 patients (45%) who were significantly younger (10.8±4.0 vs 13.0 ±4.9 years), had lower BMI percentile (46 ±32 vs. 63 ±34) with more episodes of weekly diarrhea (20 vs. 13) (for each, p < 0.05).Primary diagnoses following endoscopy were disaccharidase deficiency (28%), celiac disease (22%), duodenitis/ulcer (10%), IBD (10%), esophagitis/EoE (10%), gastropathies/ulcers (12%) and other diagnoses (21%). Among the 62 patients for whom follow-up information was available, 17 of 22 (72%) responded to diet changes alone; 10 of 16 (62%) responded to medications; and 14 of 19 (74%) responded to both diet changes and medication. In the diet group, 4 of 5 (80%) improved on diet changes and sucrase supplement; 11 of 16 (69%) responded to lactase restriction; and 1 of 2 (50%) responded when both were addressed; 18 of 23 (78%) responded to gluten-free or elimination diets. Conclusion: SD appears to be more prevalent than previously suspected and often occurs in tandem with LD. The full clinical picture, optimal diagnostic method and appropriate treatment algorithm for children and adults with SD need to be established by further research." @default.
• W2977997680 created "2019-10-10" @default.
• W2977997680 creator A5013001786 @default.
• W2977997680 creator A5084855607 @default.
• W2977997680 date "2015-10-01" @default.
• W2977997680 modified "2023-09-27" @default.
• W2977997680 title "Clinical Characteristics of Children With Sucrase Deficiency Found on Diagnostic Esophagogastroduodenoscopy (EGD)" @default.
• W2977997680 doi "https://doi.org/10.14309/00000434-201510001-02235" @default.
• W2977997680 hasPublicationYear "2015" @default.
• W2977997680 type Work @default.
• W2977997680 sameAs 2977997680 @default.
• W2977997680 citedByCount "0" @default.
• W2977997680 crossrefType "journal-article" @default.
• W2977997680 hasAuthorship W2977997680A5013001786 @default.
• W2977997680 hasAuthorship W2977997680A5084855607 @default.
• W2977997680 hasConcept C126322002 @default.
• W2977997680 hasConcept C146201443 @default.
• W2977997680 hasConcept C178790620 @default.
• W2977997680 hasConcept C185592680 @default.
• W2977997680 hasConcept C2775913212 @default.
• W2977997680 hasConcept C2776956441 @default.
• W2977997680 hasConcept C2777432071 @default.
• W2977997680 hasConcept C2777882243 @default.
• W2977997680 hasConcept C2778451229 @default.
• W2977997680 hasConcept C2778724459 @default.
• W2977997680 hasConcept C2778974006 @default.
• W2977997680 hasConcept C2779802037 @default.
• W2977997680 hasConcept C2780955771 @default.
• W2977997680 hasConcept C2781143854 @default.
• W2977997680 hasConcept C71924100 @default.
• W2977997680 hasConcept C90924648 @default.
• W2977997680 hasConceptScore W2977997680C126322002 @default.
• W2977997680 hasConceptScore W2977997680C146201443 @default.
• W2977997680 hasConceptScore W2977997680C178790620 @default.
• W2977997680 hasConceptScore W2977997680C185592680 @default.
• W2977997680 hasConceptScore W2977997680C2775913212 @default.
• W2977997680 hasConceptScore W2977997680C2776956441 @default.
• W2977997680 hasConceptScore W2977997680C2777432071 @default.
• W2977997680 hasConceptScore W2977997680C2777882243 @default.
• W2977997680 hasConceptScore W2977997680C2778451229 @default.
• W2977997680 hasConceptScore W2977997680C2778724459 @default.
• W2977997680 hasConceptScore W2977997680C2778974006 @default.
• W2977997680 hasConceptScore W2977997680C2779802037 @default.
• W2977997680 hasConceptScore W2977997680C2780955771 @default.
• W2977997680 hasConceptScore W2977997680C2781143854 @default.
• W2977997680 hasConceptScore W2977997680C71924100 @default.
• W2977997680 hasConceptScore W2977997680C90924648 @default.
• W2977997680 hasLocation W29779976801 @default.
• W2977997680 hasOpenAccess W2977997680 @default.
• W2977997680 hasPrimaryLocation W29779976801 @default.
• W2977997680 hasRelatedWork W124537736 @default.
• W2977997680 hasRelatedWork W1955600427 @default.
• W2977997680 hasRelatedWork W2047609279 @default.
• W2977997680 hasRelatedWork W2110095273 @default.
• W2977997680 hasRelatedWork W2344061790 @default.
• W2977997680 hasRelatedWork W2425476755 @default.
• W2977997680 hasRelatedWork W2914921795 @default.
• W2977997680 hasRelatedWork W2977997680 @default.
• W2977997680 hasRelatedWork W3210322031 @default.
• W2977997680 hasRelatedWork W4316078140 @default.
• W2977997680 hasVolume "110" @default.
• W2977997680 isParatext "false" @default.
• W2977997680 isRetracted "false" @default.
• W2977997680 magId "2977997680" @default.
• W2977997680 workType "article" @default.