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- W2978002966 abstract "Objective To investigate the expression and clinical significance of maspin,uPA,VEGF and VEGF-C in gastrointestinal stromal tumor(GIST) patients.Methods The expression of maspin,uPA,VEGF and VEGF-C were detected by immunohistochemistry and RT-PCR,respectively.The relations between the expression of each factor and biological behavior and the correlation among maspin and uPA,VEGF as well as VEGF-C were respectively analyzed.Results In 42 GISTs tissues,the protein expression rates of maspin,uPA,VEGF and VEGF-C were 61.9%(26/42),64.3%(27/42),59.5%(25/42)and 54.8%(23/42),respectively.RT-PCR indicated that the mRNA of maspin,uPA,VEGF and VEGF-C also distributed extensively in GIST groups and were coincident with the protein changes.With the increase of the invasion risk,the positive expression of maspin was reduced and the positive expression of uPA protein,VEGF and VEGF-C protein were increased(P0.05).The uPA mRNA expression did not show obvious difference(P0.05).The positive expression of maspin statistically decreased and that of VEGF and VEGF-C significantly increased with recurrence or metastasis(P0.05).uPA expression had no significant relation with recurrence or metastasis(P0.05).There were significant negative correlation between the expression of maspin and that of uPA,VEGF and VEGF-C,respectively(r=-0.429,P0.05;r=-0.312,P0.05;r=-0.292,P0.05).Conclusion Reduced or absent expression of maspin promotes up-regulation of uPA,VEGF and VEGF-C expression,which might play an important role in tumor progression of GIST.And maspin,uPA,VEGF and VEGF-C will be important factors in predicting GIST biological behaviour and judging prognosis,and maspin gene may be a new target for GIST targeted therapy." @default.
- W2978002966 created "2019-10-10" @default.
- W2978002966 creator A5058979964 @default.
- W2978002966 date "2011-01-01" @default.
- W2978002966 modified "2023-09-23" @default.
- W2978002966 title "Expression and clinicopathological significance of maspin,uPA,VEGF and VEGF-C in patients with gastrointestinal stromal tumor" @default.
- W2978002966 hasPublicationYear "2011" @default.
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