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- W2978009873 abstract "Purpose: BP are widely used for prevention and treatment of osteoporosis. BP can cause erosive esophagitis and delay healing. According to some, chronic use of BP may be associated with an increased risk of esophageal cancer. Epidemiological studies have evaluated the relationship between BP and the risk of esophageal cancer. However, the results are conflicting. Methods: We performed a systematic review and meta-analysis of controlled observational studies to examine the association of BP use and the risks of esophageal cancer through a meta-analysis of studies published on this subject in peer-reviewed literature. A comprehensive search of MEDLINE from 1950-2012 was conducted. We also scanned the bibliographies of all retrieved articles for additional relevant articles. All controlled observational studies that compared esophageal cancer outcome in patients with BP to control group were included. We extracted adjusted effect estimates with standard error and calculated pooled odds ratios (ORs) and 95% confidence intervals (CI) using a random effects model (REM). The Cochrane Q X2 test was used to detect heterogeneity of the effects. Results: Of 42 identified studies, 6 (3 cohort and 3 case-control) with 3,570 esophageal cancer patients were included in our analysis. Of these, 5 studies were performed in western countries, one in Taiwan. In BP users, compared with non users, the pooled OR for esophageal cancer was 1.02 (95% CI, 0.73-1.42), with no significant heterogeneity between studies (P=0.15). Sensitivity analysis was performed: 1) analysis that included only studies published in full-text form (n=3); and 2) study designs (cohort vs case-control). The pooled OR of the case control studies was marginally significant (OR 1.28, 95% CI, 1.01-1.63). Otherwise, we did not find any major changes in direction and magnitude of the summary estimates and p value of heterogeneity. Conclusion: We found no association of oral BP and the increased risk of esophageal cancer at the population level." @default.
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- W2978009873 date "2012-10-01" @default.
- W2978009873 modified "2023-09-25" @default.
- W2978009873 title "Bisphosphonates (BP) and Risk of Esophageal Cancer: A Meta Analysis of Observational Studies" @default.
- W2978009873 doi "https://doi.org/10.14309/00000434-201210001-00042" @default.
- W2978009873 hasPublicationYear "2012" @default.
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