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• W2978012008 abstract "Introduction: One in four patients with human immunodeficiency virus (HIV) is co-infected with hepatitis c virus (HCV) in the United States. Sustained viral response (SVR) rates after treatment with interferon (IFN)-based regimens were worse in co-infected than in mono-infected patients. SVR rates after treatment with direct-acting antiviral agents (DAA) are much higher in both mono-infection and co-infection in published clinical trials. We compared SVR rates in the DAA era in the HCV-HIV coinfected and mono-infected patients with HCV genotype 1 (GT1) in an inner-city population with high prevalence of HCV and HIV. Methods: This was a retrospective cohort study of all patients with HCV GT1 who underwent treatment for HCV with dual DAA regimens at our institution. Patients with incomplete records and pending SVR results were excluded from analysis. Treatment regimens included: (1) ledipasvir/sofosbuvir, (2) ombitasvir/paritaprevir/dasabuvir/ritonavir and (3) simeprevir/sofosbuvir. The primary outcome was SVR 12 rates in co-infected and mono-infected patients. Fishers exact test was used to determine statistical signifi cance of differences between the groups while multivariate logistic regression was used to determine factors independently influencing SVR. Results: In total, 60 patients were treated in the co-infection group and 181 in the mono-infected group. The mean age for HCV-HIV and HCV cohorts were 54 and 59 years; 74% and 57% of the patients were male in the HCV-HIV and HCV groups, respectively. African-Americans accounted for 45% of the patients in both groups, while 37% and 32% were Hispanic, and 18% and 14% were Caucasians in the HCV-HIV and HCV groups, respectively. The prevalence of F4 fibrosis by APRI was 28.3% in the coinfected and 30.6% in the mono-infected group. SVR rates for co-infected patients were 91.6% compared to 95% in the mono-infected patient population (p=0.34). Multivariate logistic regression adjusting for factors that were deemed significant on the univariate regression showed that only age impacted treatment outcomes in the mono-infected groups where as age and disease stage affected treatment outcomes in the co-infected group. Conclusion: Our study shows that there was no statistically significant difference in SVR rates in the HIV-HCV co-infected and mono-infected patients receiving 2 or more DAA's agents. Disease stage affects treatment outcomes in co-infected patients but had no impact on HCV mono-infected patients." @default.
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• W2978012008 date "2016-10-01" @default.
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• W2978012008 title "Treatment Outcomes in HCV-HIV Co-infected Patients in an Inner-city Hospital" @default.
• W2978012008 doi "https://doi.org/10.14309/00000434-201610001-00863" @default.
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