Matches in SemOpenAlex for { <https://semopenalex.org/work/W2978024657> ?p ?o ?g. }
- W2978024657 endingPage "2143" @default.
- W2978024657 startingPage "2135" @default.
- W2978024657 abstract "Advances in our understanding of mechanisms of leukemogenesis and driver mutations in acute lymphoblastic leukemia (ALL) lead to a more precise and informative sub-classification, mainly of B-cell ALL. In parallel, in recent years, novel agents have been approved for the therapy of B-cell ALL, and many others are in active clinical research. Among the newly recognized disease subtypes, Philadelphia-chromosome-like ALL is the most heterogeneous and thus, diagnostically challenging. Given that this subtype of B-cell ALL is associated with a poorer prognosis, improvement of available therapeutic approaches and protocols is a burning issue. Herein, we summarize, in a clinically relevant manner, up-to-date information regarding diagnostic strategies developed for the identification of patients with Philadelphia-chromosome-like ALL. Common therapeutic dilemmas, presented as several case scenarios, are also discussed. It is currently acceptable that patients with B-cell ALL, treated with an aim of cure, irrespective of their age, be evaluated for a Philadelphia-chromosome-like signature as early as possible. Following Philadelphia-chromosome-like recognition, a higher risk of resistance or relapse must be realized and treatment should be modified based on the patient’s specific genetic driver and clinical features. However, while active targeted therapeutic options are limited, there is much more to do than just prescribe a matched inhibitor to the identified mutated driver genes. In this review, we present a comprehensive evidence-based approach to the diagnosis and management of Philadelphia-chromosome-like ALL at different time-points during the disease course." @default.
- W2978024657 created "2019-10-10" @default.
- W2978024657 creator A5032731817 @default.
- W2978024657 creator A5085103789 @default.
- W2978024657 date "2019-10-03" @default.
- W2978024657 modified "2023-09-26" @default.
- W2978024657 title "How I diagnose and manage Philadelphia chromosome-like acute lymphoblastic leukemia" @default.
- W2978024657 cites W1751666365 @default.
- W2978024657 cites W1840489083 @default.
- W2978024657 cites W1870543278 @default.
- W2978024657 cites W1961598494 @default.
- W2978024657 cites W1967348190 @default.
- W2978024657 cites W1968151924 @default.
- W2978024657 cites W1976875080 @default.
- W2978024657 cites W1980746962 @default.
- W2978024657 cites W1986495031 @default.
- W2978024657 cites W1987175802 @default.
- W2978024657 cites W2000266274 @default.
- W2978024657 cites W2001480397 @default.
- W2978024657 cites W2004097969 @default.
- W2978024657 cites W2012114257 @default.
- W2978024657 cites W2013194301 @default.
- W2978024657 cites W2022941976 @default.
- W2978024657 cites W2024996887 @default.
- W2978024657 cites W2028539310 @default.
- W2978024657 cites W2031803874 @default.
- W2978024657 cites W2034920499 @default.
- W2978024657 cites W2036999612 @default.
- W2978024657 cites W2037104393 @default.
- W2978024657 cites W2040329520 @default.
- W2978024657 cites W2047154875 @default.
- W2978024657 cites W2047522348 @default.
- W2978024657 cites W2053754416 @default.
- W2978024657 cites W2058171758 @default.
- W2978024657 cites W2062043705 @default.
- W2978024657 cites W2063076610 @default.
- W2978024657 cites W2066868518 @default.
- W2978024657 cites W2069709802 @default.
- W2978024657 cites W2071700698 @default.
- W2978024657 cites W2071818770 @default.
- W2978024657 cites W2075043727 @default.
- W2978024657 cites W2087497315 @default.
- W2978024657 cites W2087529065 @default.
- W2978024657 cites W2092157777 @default.
- W2978024657 cites W2096709475 @default.
- W2978024657 cites W2104722860 @default.
- W2978024657 cites W2105345844 @default.
- W2978024657 cites W2118796952 @default.
- W2978024657 cites W2119240494 @default.
- W2978024657 cites W2130299150 @default.
- W2978024657 cites W2136157904 @default.
- W2978024657 cites W2145968395 @default.
- W2978024657 cites W2148202982 @default.
- W2978024657 cites W2148631711 @default.
- W2978024657 cites W2154410907 @default.
- W2978024657 cites W2158932180 @default.
- W2978024657 cites W2200335683 @default.
- W2978024657 cites W2254345040 @default.
- W2978024657 cites W2333877478 @default.
- W2978024657 cites W2336096370 @default.
- W2978024657 cites W2343155427 @default.
- W2978024657 cites W2419639370 @default.
- W2978024657 cites W2464630776 @default.
- W2978024657 cites W2511191041 @default.
- W2978024657 cites W2513488453 @default.
- W2978024657 cites W2520019384 @default.
- W2978024657 cites W2520695016 @default.
- W2978024657 cites W2529226476 @default.
- W2978024657 cites W2530177575 @default.
- W2978024657 cites W2534055440 @default.
- W2978024657 cites W2544154715 @default.
- W2978024657 cites W2547027362 @default.
- W2978024657 cites W2551081698 @default.
- W2978024657 cites W2551231092 @default.
- W2978024657 cites W2554580516 @default.
- W2978024657 cites W2555714800 @default.
- W2978024657 cites W2557296082 @default.
- W2978024657 cites W2560140376 @default.
- W2978024657 cites W2570081494 @default.
- W2978024657 cites W2591709377 @default.
- W2978024657 cites W2596667846 @default.
- W2978024657 cites W2607221715 @default.
- W2978024657 cites W2612868058 @default.
- W2978024657 cites W2625451824 @default.
- W2978024657 cites W2643917880 @default.
- W2978024657 cites W2697407604 @default.
- W2978024657 cites W2757339809 @default.
- W2978024657 cites W2768506552 @default.
- W2978024657 cites W2769895972 @default.
- W2978024657 cites W2775805345 @default.
- W2978024657 cites W2783032930 @default.
- W2978024657 cites W2787145330 @default.
- W2978024657 cites W2787301955 @default.
- W2978024657 cites W2787621143 @default.
- W2978024657 cites W2789537253 @default.
- W2978024657 cites W2794405738 @default.
- W2978024657 cites W2800118768 @default.
- W2978024657 cites W2804736789 @default.