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• W2978072975 abstract "Introduction: Recent cross-sectional analysis of data from the Third National Health and Nutrition Examination Survey (NHANES III) found that regular aspirin use was associated with a lower prevalence of NAFLD diagnosed by ultrasonography. Studies in animal models of NAFLD have suggested that aspirin may attenuate liver steatosis, inflammation and fibrosis. The present study aimed to assess the impact of aspirin use on histological features in patients with biopsy-proven NAFLD. Methods: We conducted a retrospective analysis of all adult patients diagnosed with NAFLD based on liver biopsy between 2005 and 2014. Histology was assessed by an experienced pathologist. Steatosis, lobular inflammation, and hepatocyte ballooning were graded according to the NAFLD activity score (NAS) and fibrosis was staged from F0-F4. Comparisons between subjects on and off aspirin were done using analysis of variance (ANOVA), the non-parametric Kruskal-Wallis tests, and Pearson's chi-square tests as appropriate. A p-value < 0.05 was considered statistically significant. Results: A total of 186 subjects with biopsy-proven NAFLD were included in the analysis; 48 subjects (26%) were using aspirin (37 on 81 mg, and 11 on 325 mg daily) and compared to 138 patients without aspirin use. Patients on aspirin were significantly older (55.6 vs. 50.1 years), and more likely to have hypertension, dyslipidemia, take ACE inhibitors, and statins; p value < 0.05 for all. Patients on aspirin were more likely to have grade 1 steatosis (55.1% vs. 32.6%) and less likely to have grade 3 steatosis (4.1% vs. 22.5%) compared to those not on aspirin; p = 0.019. However, there was no significant difference between the groups in respect to inflammation, hepatocyte ballooning, the overall NAS, and fibrosis stage. Of note, the patients taking aspirin 325 mg daily were less likely to have inflammation, ballooning, fibrosis, and definite NASH on biopsy compared to patients on 81 mg daily or those not taking aspirin, but this did not reach statistical significance potentially due to the small sample size (only 11 patients in the 325 mg daily group). Conclusion: Although daily aspirin use may be associated with less severe liver steatosis in NAFLD patients, it had no significant effect on the other histological features. Future studies to investigate the role of aspirin at 325 mg daily need to be conducted." @default.
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• W2978072975 date "2015-10-01" @default.
• W2978072975 modified "2023-10-18" @default.
• W2978072975 title "The Impact of Aspirin Use on Liver Histology in Patients With Nonalcoholic Fatty Liver Disease (NAFLD)" @default.
• W2978072975 doi "https://doi.org/10.14309/00000434-201510001-02135" @default.
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