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- W2978073668 abstract "Abstract Hemispheric asymmetry in neuronal processes is a fundamental feature of the human brain and drives symptom lateralization in Parkinson’s disease (PD), but its molecular determinants are unknown. Here, we determine epigenetic differences involved in hemispheric asymmetry in the healthy and the PD brain. Neurons of the healthy brain exhibit numerous hemispheric differences in DNA methylation, which affect genes implicated in neurodegenerative diseases. In PD patients, hemispheric asymmetry in DNA methylation is even greater and involves many PD risk genes. The lateralization of clinical PD symptoms involves epigenetic, transcriptional, and proteomic differences across hemispheres that affect neurodevelopment, immune activation, and synaptic transmission. During aging, healthy neurons show a progressive loss of hemispheric asymmetry in the epigenome, which is amplified in PD. For PD patients, a long disease course is associated with greater hemispheric asymmetry in neuronal epigenomes than a short disease course. Hemispheric differences in epigenetic gene regulation are prevalent in neurons and may affect the progression and symptoms of PD." @default.
- W2978073668 created "2019-10-10" @default.
- W2978073668 creator A5021778994 @default.
- W2978073668 creator A5028948760 @default.
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- W2978073668 creator A5054099209 @default.
- W2978073668 creator A5078501123 @default.
- W2978073668 creator A5086118916 @default.
- W2978073668 date "2019-10-07" @default.
- W2978073668 modified "2023-10-17" @default.
- W2978073668 title "Epigenetic contributions to hemisphere asymmetry in healthy brain, aging, and Parkinson’s disease" @default.
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