FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2978074313> ?p ?o ?g. }

• W2978074313 endingPage "525" @default.
• W2978074313 startingPage "510" @default.
• W2978074313 abstract "Our goal was to understand the impact of regenerative therapies on the functional capacity of skeletal muscle following volumetric muscle loss (VML) injury. An extensive database search (e.g., PubMed, Cochrane Library, and ClinicalTrials.gov) was conducted up through January 2019 to evaluate the following: In humans or animals with VML injury, is treatment better than no treatment at recovering functional capacity? Study eligibility criteria required studies to have both an untreated and at least one treated VML injury group. From 2312 study reports, 44 studies met the inclusion criteria. Quantitative functional capacity data (absolute and/or normalized strength) or proportional measures (histological analysis quantifying viable muscle tissue, mitochondrial function, and/or exhaustive treadmill running) were extracted for use. While both human and animal studies were included in the searches, only animal studies met the eligibility criteria. Using a random-effects model, Hedges' g was used as the effect size (ES) and calculated such that a positive ES indicated treatment efficacy. The overall ES was 0.75 (95% confidence interval: 0.53-0.96; p < 0.0000001), indicating that the treatments, on average, resulted in a significant improvement in functional capacity. From network meta-analyses, it was determined that an acellular biomaterial combined with stem and/or progenitor cells had the greatest treatment effectiveness. The findings indicate that various treatments in animal models of VML improve the functional capacity of muscle compared to leaving the injury untreated; however, the ∼16% beneficial effect is small. Our results suggest that current regenerative therapy paradigms require further maturation to achieve clinically meaningful improvements in the functional capacity of the muscle. Impact Statement Our most salient findings are that (1) various treatment approaches used in animal models of volumetric muscle loss (VML) injury improve functional capacity compared to leaving the injury untreated and (2) an acellular biomaterial in combination with cellular components was the most effective treatment to improve functional capacity following VML injury to date. The nature of our findings has substantial implications for regenerative medicine, biomedical engineering, and rehabilitative techniques currently being evaluated and developed for VML injury repair, and are pivotal to the progression of the regenerative medicine effort aimed at restoring maximal function to traumatized and disabled limbs." @default.
• W2978074313 created "2019-10-10" @default.
• W2978074313 creator A5017884005 @default.
• W2978074313 creator A5025487562 @default.
• W2978074313 creator A5033455118 @default.
• W2978074313 creator A5042196872 @default.
• W2978074313 creator A5080250954 @default.
• W2978074313 date "2019-12-01" @default.
• W2978074313 modified "2023-10-13" @default.
• W2978074313 title "Therapeutic Approaches for Volumetric Muscle Loss Injury: A Systematic Review and Meta-Analysis" @default.
• W2978074313 cites W1007294394 @default.
• W2978074313 cites W1482003625 @default.
• W2978074313 cites W1557667811 @default.
• W2978074313 cites W1562372720 @default.
• W2978074313 cites W1603293637 @default.
• W2978074313 cites W1756269602 @default.
• W2978074313 cites W1856771337 @default.
• W2978074313 cites W1887760770 @default.
• W2978074313 cites W1928840956 @default.
• W2978074313 cites W1949368962 @default.
• W2978074313 cites W1972201752 @default.
• W2978074313 cites W1974517758 @default.
• W2978074313 cites W1982571807 @default.
• W2978074313 cites W1985199900 @default.
• W2978074313 cites W1987054300 @default.
• W2978074313 cites W1991380378 @default.
• W2978074313 cites W1992277292 @default.
• W2978074313 cites W1993595739 @default.
• W2978074313 cites W2004001595 @default.
• W2978074313 cites W2012418589 @default.
• W2978074313 cites W2025503850 @default.
• W2978074313 cites W2025852006 @default.
• W2978074313 cites W2030527446 @default.
• W2978074313 cites W2056975162 @default.
• W2978074313 cites W2068236138 @default.
• W2978074313 cites W2069016577 @default.
• W2978074313 cites W2069058065 @default.
• W2978074313 cites W2084113440 @default.
• W2978074313 cites W2087406252 @default.
• W2978074313 cites W2088843448 @default.
• W2978074313 cites W2088883625 @default.
• W2978074313 cites W2097304128 @default.
• W2978074313 cites W2098923148 @default.
• W2978074313 cites W2099540110 @default.
• W2978074313 cites W2107614370 @default.
• W2978074313 cites W2114033160 @default.
• W2978074313 cites W2114608470 @default.
• W2978074313 cites W2116040003 @default.
• W2978074313 cites W2137876182 @default.
• W2978074313 cites W2143082806 @default.
• W2978074313 cites W2145437687 @default.
• W2978074313 cites W2147214102 @default.
• W2978074313 cites W2163883109 @default.
• W2978074313 cites W2336642884 @default.
• W2978074313 cites W2341057301 @default.
• W2978074313 cites W2474756239 @default.
• W2978074313 cites W2476972561 @default.
• W2978074313 cites W2494364118 @default.
• W2978074313 cites W2516563439 @default.
• W2978074313 cites W2551014352 @default.
• W2978074313 cites W2551181982 @default.
• W2978074313 cites W2554076484 @default.
• W2978074313 cites W2560151895 @default.
• W2978074313 cites W2585860091 @default.
• W2978074313 cites W2607191623 @default.
• W2978074313 cites W2610293228 @default.
• W2978074313 cites W2674270813 @default.
• W2978074313 cites W2761299361 @default.
• W2978074313 cites W2766765254 @default.
• W2978074313 cites W2767944780 @default.
• W2978074313 cites W2768526122 @default.
• W2978074313 cites W2770518147 @default.
• W2978074313 cites W2782584141 @default.
• W2978074313 cites W2794005333 @default.
• W2978074313 cites W2800380986 @default.
• W2978074313 cites W2805250866 @default.
• W2978074313 cites W2805296735 @default.
• W2978074313 cites W2896105548 @default.
• W2978074313 cites W2896911168 @default.
• W2978074313 cites W2900882142 @default.
• W2978074313 cites W2911589743 @default.
• W2978074313 cites W2911955002 @default.
• W2978074313 cites W4243747196 @default.
• W2978074313 cites W4297918764 @default.
• W2978074313 cites W60570984 @default.
• W2978074313 cites W935312422 @default.
• W2978074313 doi "https://doi.org/10.1089/ten.teb.2019.0207" @default.
• W2978074313 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31578930" @default.
• W2978074313 hasPublicationYear "2019" @default.
• W2978074313 type Work @default.
• W2978074313 sameAs 2978074313 @default.
• W2978074313 citedByCount "65" @default.
• W2978074313 countsByYear W29780743132020 @default.
• W2978074313 countsByYear W29780743132021 @default.
• W2978074313 countsByYear W29780743132022 @default.
• W2978074313 countsByYear W29780743132023 @default.
• W2978074313 crossrefType "journal-article" @default.
• W2978074313 hasAuthorship W2978074313A5017884005 @default.

• next