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- W2978082170 abstract "Objective To investigate the cellular pathophysiology mechanism of peritoneal adhe- sion induced by trauma or infection.Methods Two hundred and forty healthy Wistar rats were ran- domly divided into three groups(trauma group,trauma+infection group,and control group).The sta- tus of adhesion was observed by HE staining,and the serum levels of TNF,IL-6,PAI and t-PA were simultaneously measured on 1,3,7 and 14 days.Macrophages,mesothelial cells and fibroblasts were i- solated and cultured.Biomarkers including TNF,IL-6,PAI and t-PA were measured and the prolifera- ting activity of the above cells was analyzed after pretreatment with LPS,TGF or TNF.Results Mac- rophage was activated after infection,inflammation or mesothelial cell injury and secreted inflammatory factors and PAI.Pretreatment with LPS,TGF-or cytokine promoted the proliferating activity of fibro- blast while local inflammation suppressed mesothelial cell's repair and secretory activity.Conclusions Mesothelial cell injury,macrophage activation,fiber exudation and fibroblast proliferation all contribu- ted to the formation of peritoneal adhesion.The whole process may include intra-abdominal infection, inflammation,fiber exudation,matrix formation as well as fibroblast proliferation,migration and fibro- sis." @default.
- W2978082170 created "2019-10-10" @default.
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- W2978082170 date "2007-01-01" @default.
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- W2978082170 title "The research of the cellular pathophysiology mechanism in the process of peritoneal adhesion" @default.
- W2978082170 hasPublicationYear "2007" @default.
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