Matches in SemOpenAlex for { <https://semopenalex.org/work/W2978133139> ?p ?o ?g. }
- W2978133139 endingPage "484" @default.
- W2978133139 startingPage "475" @default.
- W2978133139 abstract "To estimate the overall rate, symptomatic proportion, and most common sites of pelvic insufficiency fracture (PIF) after external beam radiation therapy for gynecologic cancers based on posttreatment computed tomography, magnetic resonance imaging, positron emission tomography, or bone scintigraphy.A systematic search of databases (PubMed and EMBASE) was performed (CRD42019125679). The pooled summary of overall PIF and the proportion of symptomatic cases were calculated using the random-effects model weighted by the inverse variance. A multivariate meta-regression was performed to evaluate potential sources of heterogeneity regarding PIF fractures.Twenty-one studies met the inclusion criteria (total 3929 patients). Five hundred four patients developed PIF, translating to an overall rate of 14% (95% confidence interval, 10%-18%, based on 21 studies). Among these cases with PIF, the proportion of symptomatic patients was 61% (95% confidence interval, 52%-69%, based on 14 studies). The total number of PIFs was 704 (mean, 1.72 PIFs per each patient to develop PIF, based on 14 studies). More recent series (P = .0074) and the use of intensity modulated radiation therapy (P = .0299) were associated with lower fracture rates. The most common fracture sites were sacroiliac joint (39.7%), body of the sacrum (33.9%), pubis (13%), lumbar vertebra (7%), iliac bone (2.8%), acetabulum (2.1%), and femoral head/neck (1.5%). The median time to fracture was 7.1 to 19 months after radiation therapy.The incidence of PIF after radiation therapy for gynecologic cancers is high (14%), with the majority affecting the sacral bone or joint (73.6%), although this risk appears to be lower with intensity modulated radiation therapy. Posttreatment bone surveillance is warranted in this population because nearly 40% of patients were asymptomatic at the time of PIF diagnosis." @default.
- W2978133139 created "2019-10-10" @default.
- W2978133139 creator A5003962206 @default.
- W2978133139 creator A5024043125 @default.
- W2978133139 creator A5028525578 @default.
- W2978133139 creator A5040402497 @default.
- W2978133139 creator A5041813027 @default.
- W2978133139 creator A5044984109 @default.
- W2978133139 creator A5060019145 @default.
- W2978133139 creator A5079236834 @default.
- W2978133139 creator A5080935101 @default.
- W2978133139 creator A5084294053 @default.
- W2978133139 date "2020-03-01" @default.
- W2978133139 modified "2023-10-05" @default.
- W2978133139 title "Pelvic Insufficiency Fractures After External Beam Radiation Therapy for Gynecologic Cancers: A Meta-analysis and Meta-regression of 3929 Patients" @default.
- W2978133139 cites W1497860031 @default.
- W2978133139 cites W1543792203 @default.
- W2978133139 cites W1977336247 @default.
- W2978133139 cites W1988389140 @default.
- W2978133139 cites W1990405213 @default.
- W2978133139 cites W1990658356 @default.
- W2978133139 cites W1996449375 @default.
- W2978133139 cites W2022250299 @default.
- W2978133139 cites W2035534534 @default.
- W2978133139 cites W2062862249 @default.
- W2978133139 cites W2063056802 @default.
- W2978133139 cites W2066217357 @default.
- W2978133139 cites W2087031244 @default.
- W2978133139 cites W2097623415 @default.
- W2978133139 cites W2099198422 @default.
- W2978133139 cites W2100923989 @default.
- W2978133139 cites W2103026252 @default.
- W2978133139 cites W2105936312 @default.
- W2978133139 cites W2106278786 @default.
- W2978133139 cites W2112629831 @default.
- W2978133139 cites W2116888950 @default.
- W2978133139 cites W2124527463 @default.
- W2978133139 cites W2134852288 @default.
- W2978133139 cites W2151180223 @default.
- W2978133139 cites W2153009489 @default.
- W2978133139 cites W2161837912 @default.
- W2978133139 cites W2163375614 @default.
- W2978133139 cites W2275737843 @default.
- W2978133139 cites W2335178464 @default.
- W2978133139 cites W2467738283 @default.
- W2978133139 cites W2528813605 @default.
- W2978133139 cites W2538903536 @default.
- W2978133139 cites W2602377655 @default.
- W2978133139 cites W2604689121 @default.
- W2978133139 cites W2766115879 @default.
- W2978133139 cites W2889646458 @default.
- W2978133139 cites W2897047026 @default.
- W2978133139 cites W4243302980 @default.
- W2978133139 cites W4294215472 @default.
- W2978133139 doi "https://doi.org/10.1016/j.ijrobp.2019.09.012" @default.
- W2978133139 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31580930" @default.
- W2978133139 hasPublicationYear "2020" @default.
- W2978133139 type Work @default.
- W2978133139 sameAs 2978133139 @default.
- W2978133139 citedByCount "44" @default.
- W2978133139 countsByYear W29781331392020 @default.
- W2978133139 countsByYear W29781331392021 @default.
- W2978133139 countsByYear W29781331392022 @default.
- W2978133139 countsByYear W29781331392023 @default.
- W2978133139 crossrefType "journal-article" @default.
- W2978133139 hasAuthorship W2978133139A5003962206 @default.
- W2978133139 hasAuthorship W2978133139A5024043125 @default.
- W2978133139 hasAuthorship W2978133139A5028525578 @default.
- W2978133139 hasAuthorship W2978133139A5040402497 @default.
- W2978133139 hasAuthorship W2978133139A5041813027 @default.
- W2978133139 hasAuthorship W2978133139A5044984109 @default.
- W2978133139 hasAuthorship W2978133139A5060019145 @default.
- W2978133139 hasAuthorship W2978133139A5079236834 @default.
- W2978133139 hasAuthorship W2978133139A5080935101 @default.
- W2978133139 hasAuthorship W2978133139A5084294053 @default.
- W2978133139 hasConcept C126322002 @default.
- W2978133139 hasConcept C126838900 @default.
- W2978133139 hasConcept C141071460 @default.
- W2978133139 hasConcept C143409427 @default.
- W2978133139 hasConcept C2776541429 @default.
- W2978133139 hasConcept C2779455797 @default.
- W2978133139 hasConcept C2911105243 @default.
- W2978133139 hasConcept C2989005 @default.
- W2978133139 hasConcept C44249647 @default.
- W2978133139 hasConcept C44575665 @default.
- W2978133139 hasConcept C509974204 @default.
- W2978133139 hasConcept C71924100 @default.
- W2978133139 hasConcept C95190672 @default.
- W2978133139 hasConceptScore W2978133139C126322002 @default.
- W2978133139 hasConceptScore W2978133139C126838900 @default.
- W2978133139 hasConceptScore W2978133139C141071460 @default.
- W2978133139 hasConceptScore W2978133139C143409427 @default.
- W2978133139 hasConceptScore W2978133139C2776541429 @default.
- W2978133139 hasConceptScore W2978133139C2779455797 @default.
- W2978133139 hasConceptScore W2978133139C2911105243 @default.
- W2978133139 hasConceptScore W2978133139C2989005 @default.
- W2978133139 hasConceptScore W2978133139C44249647 @default.
- W2978133139 hasConceptScore W2978133139C44575665 @default.