Matches in SemOpenAlex for { <https://semopenalex.org/work/W2978163485> ?p ?o ?g. }
Showing items 1 to 54 of
54
with 100 items per page.
- W2978163485 endingPage "v841" @default.
- W2978163485 startingPage "v841" @default.
- W2978163485 abstract "Abstract Background CART-19 therapy is an immunotherapy treatment based in extracorporeal and synthetic modification of T-lymphocytes from the patient that goes through the therapy. This therapy is used in treatment of haematological cancers like chronic lymphocytic leukaemia (CLL) and acute lymphoblastic leukaemia (ALL) and it can be administered through one aliquot or three aliquots. It is a new therapy recently introduced in cancer treatment which introduces multiple challenges like side effects management. Its main side effect is cytokine release syndrome (CRS). The aim of this study is to compare the side effects observed in patients treated with CART-19 therapy versus side effects described in the literature. Methods This is an observational, transversal and retrospective study based in medical records review. The patients included in this study are adults treated with CART-19 therapy in Hospital Clinic Barcelona between January 2017 and April 2019. Data analysis has been done through Excel programme and taking into account clinical variables like: age, diagnosis, arterial pressure, heart rate, number of aliquots and Intensive Care Unit (UCI) requirement. Results A total of 27 CART-19 therapies have been administered. 70,4% from infusions have been done in patients with a diagnosis from ALL. The main side effects that have been observed are hypotension in a 29,6%, tachycardia in 22,2% and headache in 11,1%. Fever has been observed in a 85,2% of the infusions and it has appeared in the first 24 hours post-infusion in a 63% of the cases. A high percentage of the infusions have been administered in one aliquot (70,4%). Only in an 29,8% of the cases the patient needed a transfer to an UCI and a 22,2% needed Tocilizumab administration for CRS decrease. Conclusions The main conclusion obtained is that observed side effects in patients that have received CART-19 therapy coincide with the ones described in literature, without any new appearance. It is important to emphasise that fever has appeared in patients independent of the number of aliquots received and clinical variables affected. On the other hand, low incidence of neurological and gastrointestinal affections has been observed. Legal entity responsible for the study The authors. Funding Has not received any funding. Disclosure All authors have declared no conflicts of interest." @default.
- W2978163485 created "2019-10-10" @default.
- W2978163485 creator A5023118843 @default.
- W2978163485 creator A5024111434 @default.
- W2978163485 creator A5030004766 @default.
- W2978163485 creator A5054806560 @default.
- W2978163485 creator A5074388000 @default.
- W2978163485 creator A5081536750 @default.
- W2978163485 creator A5090527573 @default.
- W2978163485 date "2019-10-01" @default.
- W2978163485 modified "2023-09-27" @default.
- W2978163485 title "CART-19: A comparative between literature versus experience" @default.
- W2978163485 doi "https://doi.org/10.1093/annonc/mdz276.021" @default.
- W2978163485 hasPublicationYear "2019" @default.
- W2978163485 type Work @default.
- W2978163485 sameAs 2978163485 @default.
- W2978163485 citedByCount "0" @default.
- W2978163485 crossrefType "journal-article" @default.
- W2978163485 hasAuthorship W2978163485A5023118843 @default.
- W2978163485 hasAuthorship W2978163485A5024111434 @default.
- W2978163485 hasAuthorship W2978163485A5030004766 @default.
- W2978163485 hasAuthorship W2978163485A5054806560 @default.
- W2978163485 hasAuthorship W2978163485A5074388000 @default.
- W2978163485 hasAuthorship W2978163485A5081536750 @default.
- W2978163485 hasAuthorship W2978163485A5090527573 @default.
- W2978163485 hasBestOaLocation W29781634851 @default.
- W2978163485 hasConcept C166957645 @default.
- W2978163485 hasConcept C2777275308 @default.
- W2978163485 hasConcept C71924100 @default.
- W2978163485 hasConcept C95457728 @default.
- W2978163485 hasConceptScore W2978163485C166957645 @default.
- W2978163485 hasConceptScore W2978163485C2777275308 @default.
- W2978163485 hasConceptScore W2978163485C71924100 @default.
- W2978163485 hasConceptScore W2978163485C95457728 @default.
- W2978163485 hasLocation W29781634851 @default.
- W2978163485 hasOpenAccess W2978163485 @default.
- W2978163485 hasPrimaryLocation W29781634851 @default.
- W2978163485 hasRelatedWork W1995515455 @default.
- W2978163485 hasRelatedWork W2039318446 @default.
- W2978163485 hasRelatedWork W2080531066 @default.
- W2978163485 hasRelatedWork W2322350723 @default.
- W2978163485 hasRelatedWork W2748952813 @default.
- W2978163485 hasRelatedWork W2899084033 @default.
- W2978163485 hasRelatedWork W3031052312 @default.
- W2978163485 hasRelatedWork W3032375762 @default.
- W2978163485 hasRelatedWork W3108674512 @default.
- W2978163485 hasRelatedWork W3193909393 @default.
- W2978163485 hasVolume "30" @default.
- W2978163485 isParatext "false" @default.
- W2978163485 isRetracted "false" @default.
- W2978163485 magId "2978163485" @default.
- W2978163485 workType "article" @default.