Matches in SemOpenAlex for { <https://semopenalex.org/work/W2978170043> ?p ?o ?g. }
Showing items 1 to 61 of
61
with 100 items per page.
- W2978170043 endingPage "S123" @default.
- W2978170043 startingPage "S123" @default.
- W2978170043 abstract "Purpose: Clinical reports regarding long-term pioglitazone treatment for nonalcoholic fatty liver disease (NAFLD) are limited. The aim of this study was to evaluate the efficacy and safety of its administration over a long period. Methods: A total of 37 patients (19 males, 18 females; median age 62 years old) with NAFLD were enrolled. All subjects had moderately elevated ALT and ultrasonographically-proven fatty liver, while each was negative for hepatitis B and C and had a negative titer for auto-antibodies in serological examinations. None consumed alcohol. For treatment, we administered pioglitazone at 15 or 30 mg daily, and ALT, γ-GTP, FFA, TG, TC, HDL-C, HbA1c, FBS, IRI, HOMA-IR, and body weight findings were analyzed. At 24 weeks after beginning treatment, we used ALT values to classify the subjects into the Early Normalized (normal ALT) and Others groups, then analyzed clinical data using a Mann-Whitney U test. Results: ALT values improved to a normal range in 38.7% of the subjects at 24 weeks, 36.7% at 48 weeks, and 50% at 96 weeks after beginning administration of pioglitazone. Insulin sensitivity and lipid metabolism showed significant improvements. Weight gain was recognized, but it was not significant in any of the subjects. Pioglitazone treatment for 1 subject was withdrawn because of itching, while no other significant side-effects of therapy were noted in the others. Conclusion: The efficacy of long-term pioglitazone treatment for nonalcoholic fatty liver disease was satisfactory and no severe side effects from its administration were observed." @default.
- W2978170043 created "2019-10-10" @default.
- W2978170043 creator A5016389960 @default.
- W2978170043 creator A5018016302 @default.
- W2978170043 creator A5033845939 @default.
- W2978170043 date "2008-09-01" @default.
- W2978170043 modified "2023-09-26" @default.
- W2978170043 title "Efficacy and Safety of Long-Term Oral Administration of Pioglitazone for Treatment of Nonalcoholic Fatty Liver Disease" @default.
- W2978170043 doi "https://doi.org/10.14309/00000434-200809001-00317" @default.
- W2978170043 hasPublicationYear "2008" @default.
- W2978170043 type Work @default.
- W2978170043 sameAs 2978170043 @default.
- W2978170043 citedByCount "0" @default.
- W2978170043 crossrefType "journal-article" @default.
- W2978170043 hasAuthorship W2978170043A5016389960 @default.
- W2978170043 hasAuthorship W2978170043A5018016302 @default.
- W2978170043 hasAuthorship W2978170043A5033845939 @default.
- W2978170043 hasConcept C126322002 @default.
- W2978170043 hasConcept C134018914 @default.
- W2978170043 hasConcept C2776954865 @default.
- W2978170043 hasConcept C2777180221 @default.
- W2978170043 hasConcept C2778163477 @default.
- W2978170043 hasConcept C2778270857 @default.
- W2978170043 hasConcept C2778384471 @default.
- W2978170043 hasConcept C2778772119 @default.
- W2978170043 hasConcept C2779134260 @default.
- W2978170043 hasConcept C555293320 @default.
- W2978170043 hasConcept C71924100 @default.
- W2978170043 hasConcept C90924648 @default.
- W2978170043 hasConceptScore W2978170043C126322002 @default.
- W2978170043 hasConceptScore W2978170043C134018914 @default.
- W2978170043 hasConceptScore W2978170043C2776954865 @default.
- W2978170043 hasConceptScore W2978170043C2777180221 @default.
- W2978170043 hasConceptScore W2978170043C2778163477 @default.
- W2978170043 hasConceptScore W2978170043C2778270857 @default.
- W2978170043 hasConceptScore W2978170043C2778384471 @default.
- W2978170043 hasConceptScore W2978170043C2778772119 @default.
- W2978170043 hasConceptScore W2978170043C2779134260 @default.
- W2978170043 hasConceptScore W2978170043C555293320 @default.
- W2978170043 hasConceptScore W2978170043C71924100 @default.
- W2978170043 hasConceptScore W2978170043C90924648 @default.
- W2978170043 hasLocation W29781700431 @default.
- W2978170043 hasOpenAccess W2978170043 @default.
- W2978170043 hasPrimaryLocation W29781700431 @default.
- W2978170043 hasRelatedWork W1978641671 @default.
- W2978170043 hasRelatedWork W2056347555 @default.
- W2978170043 hasRelatedWork W2134384860 @default.
- W2978170043 hasRelatedWork W2378305554 @default.
- W2978170043 hasRelatedWork W2516295949 @default.
- W2978170043 hasRelatedWork W2560921027 @default.
- W2978170043 hasRelatedWork W2900203900 @default.
- W2978170043 hasRelatedWork W2991362750 @default.
- W2978170043 hasRelatedWork W2999597478 @default.
- W2978170043 hasRelatedWork W4365482011 @default.
- W2978170043 hasVolume "103" @default.
- W2978170043 isParatext "false" @default.
- W2978170043 isRetracted "false" @default.
- W2978170043 magId "2978170043" @default.
- W2978170043 workType "article" @default.