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• W2978222783 abstract "We are writing as scientists and editors of leading peer-reviewed journals that have published important contributions in the study of endocrine disrupting chemicals (EDCs). By signing this editorial, we affirm that regulatory decisions on EDCs should be made based on the best available science and expertise that involves, among others, reproductive biology, endocrinology, medicine, genetics, behaviour, developmental biology, and toxicology (American Society of Human Genetics, American Society for Reproductive Medicine, Endocrine Society, Genetics Society of America, Society for Developmental Biology, Society for Pediatric Urology, Society for the Study of Reproduction, Society for Gynecologic Investigation, 2011) (for a complete list of Signatories and their Disclosures, see Supplemental Table 1 published on The Endocrine Society's Journals Online web site at http://end.endojournals.org). Thousands of published studies have revealed the health effects of EDCs on wildlife and laboratory animals and, moreover, have shown associations of EDCs with effects in humans. Many of these studies have been reviewed recently by The Endocrine Society, the United Nations Environment Programme (UNEP) and World Health Organization (WHO), and other independent scientists (Diamanti-Kandarakis et al., 2009; Vandenberg et al., 2012; Zoeller et al., 2012; Bergman et al., 2013a). The conclusions presented in each of these documents are extraordinarily consistent: like hormones, EDCs are active at very low doses and can induce a range of adverse health outcomes, many of which are not examined in traditional toxicology assays (American Society of Human Genetics, American Society for Reproductive Medicine, Endocrine Society, Genetics Society of America, Society for Developmental Biology, Society for Pediatric Urology, Society for the Study of Reproduction, Society for Gynecologic Investigation, 2011). In sum, these reports point to the conclusion that EDCs pose a global health threat. A recent editorial signed by a number of editors of toxicology journals argues for the status quo in the regulation of EDCs (Dietrich et al., 2013), despite the large volume of evidence indicating that current regulations are ineffective in protecting human populations from these chemicals (Zoeller et al., 2012; Bergman et al., 2013a; Dietrich et al., 2013; Vandenberg et al., 2013). As the UNEP/WHO report notes, the incidence of chronic disease is now greater than that of communicable disease; many of these diseases have an endocrine basis. Both experimental animal and epidemiology studies provide plausible causal links between EDCs and many of these diseases; for some, the data are sufficiently robust (Birnbaum, 2012). The dismissive approach to endocrine disruption science put forth by Dietrich et al. (2013) is unfounded, as it is neither based on the fundamental principles of how the endocrine system works and how chemicals can interfere with its normal function nor does it consider the consequences of that interference. Their letter also ignores a growing and rigorous body of literature on both endogenous hormonal and exogenous EDC effects. Basic scientists, clinical investigators, and physicians understand that the endocrine system's functions and responses change remarkably across the life cycle. Of particular concern is incontrovertible evidence, published more than a half century ago (Phoenix et al., 1959; Wallen, 2009), that there are critical life stages, especially during early development, when hormones dictate the differentiation and development of tissues. Any perturbation of the delicate hormonal balance, whether because of the absence of natural hormones or the presence of exogenous hormones, can have irreversible effects on endocrine-sensitive organs. EDCs are known to upset this delicate balance. Dietrich et al. (2013) also misrepresent the state of science on thresholds, stating that the evidence ‘clearly demonstrates the presence of a threshold for nongenotoxic compounds including EDCs'. Dietrich et al. assert that their position constitutes ‘common sense’ and that the European Commission's approach departs from common sense. They do not, however, provide scientific support for this position. Instead, they list several references (Boobis et al., 2009; Piersma et al., 2011; Rhomberg et al., 2011; Borgert et al., 2012; Rhomberg & Goodman, 2012) that, upon examination, do not contain data supporting their assumption but rather simply assert that the assumption is true. They also fail to address the considerable literature that speaks against that assumption (e.g., Sheehan & vom Saal, 1997; vom Saal & Sheehan, 1998; Sheehan et al., 1999; Welshons et al., 2003; Sheehan, 2006). Finally, they argue that structuring regulation upon the assumption of no threshold ‘will set an unforeseen precedence [sic]’. This is simply and demonstrably not true. The assumption of no threshold has been widely used, for many years, in the regulation of genotoxic carcinogens, often based on in vitro data. We believe extending this precedent to EDCs is supported by the science (Sheehan, 2006). Furthermore, we hold that common sense dictates that policies, particularly those in which public health is at stake, should be based on scientific evidence obtained from the world's leading researchers and should derive from a more evolved, modern understanding of the science, rather than on older, outdated concepts and data taught in classrooms 20 or more years ago. The European Commission policy, by that standard, does represent ‘common sense’. Furthermore, the US National Academy of Sciences has concluded that because of the range of susceptibility to environmental chemicals across the population, such as that from age, pre-existing conditions, and genetic variation, and because there are documented exposures to multiple chemicals, including EDCs, in the population, it is more appropriate to consider lack of thresholds at a population level (vom Saal & Sheehan, 1998). Many toxicologists have developed rigorous research programs on EDCs that incorporate endocrinological principles, including two former presidents of the Society of Toxicology, Cheryl Walker and Linda Birnbaum. They and many other toxicologists do work in this area and report results that have contributed to the breadth and depth of concern about EDCs as a global public health threat. The ad hominem attacks in Dietrich et al. (2013) do nothing to advance science or opportunities to protect public health; we refer readers to two additional responses to their editorial that support this point of view (Bergman et al., 2013b; Grandjean & Ozonoff, 2013). We need the fields of toxicology, endocrinology and other stakeholders to work together to address these issues, not engage in recriminations. Policymakers in Europe and elsewhere should base their decisions on science, not on assumptions based on principles that arose out of research on chemicals that are not EDCs. The letter by Dietrich et al. does the European Commission, science, including the field of toxicology, and most importantly, public health, a profound disservice. The following is the list of signatories. The complete list of their affiliations and disclosure information is available at http://end.endojournals.org. Signatories Journal Editors-in-Chief: Prof. Jacques Balthazart, PhD, Frontiers in Neuroendocrinology; David O. Carpenter, MD, Reviews on Environmental Health; Paul Czernichow, MD, Hormone Research in Pediatrics; Donald B. DeFranco, PhD, Molecular Endocrinology; Robert M. Dores, PhD, General and Comparative Endocrinology; Andrea C. Gore, PhD, Endocrinology; David Grattan, PhD, Journal of Neuroendocrinology; Stephen R. Hammes, MD, PhD, Editor-in-Chief elect, Molecular Endocrinology; Patrick R. Hof, MD, Journal of Comparative Neurology; Carol Lange, PhD, Hormones and Cancer; Jon E. Levine, PhD, Frontiers in Neuroendocrinology; Deborah M. Power, PhD, General and Comparative Endocrinology; Professor Robert P. Millar, PhD, FRSE, Neuroendocrinology; E. Chester Ridgway, MD, MACP, Endocrine Reviews; Johannes A. Romijn, MD, PhD, European Journal of Endocrinology; Peter D. Sly, MBBS, FRACP, MD, DSc, Reviews on Environmental Health; Hubert Vaudry, PhD, DrSci, Frontiers in Neuroendocrine Science; also Senior Editor, Journal of Neuroendocrinology; Associate Editor, Hormone and Metabolic Research; Associate Editor, General and Comparative Endocrinology; Associate Editor, Peptides; Kim Wallen, PhD, Hormones and Behavior; Leonard Wartofsky, MD, MACP, Journal of Clinical Endocrinology and Metabolism; Cheryl S. Watson, PhD, Endocrine Disruptors. Journal Associate Editors: Åke Bergman, PhD, Archives of Environmental Contamination and Toxicology; Environmental Science and Pollution Research; Daniel Bikle, MD, PhD, Endocrinology; Barbara A. Cohn, PhD, Endocrine Disruptors; David Crews, PhD, Endocrine Disruptors; Journal of Experimental Zoology; Ecological Genetics and Physiology; Sexual Development; Epigenetics; Peter L. DeFur, PhD, Endocrine Disruptors; Evanthia Diamanti-Kandarakis, MD, PhD, European Journal of Endocrinology; Anthony N. Hollenberg, MD, Endocrinology; Susan Jobling, PhD, Endocrine Disruptors; Jun Kanno, MD, PhD, Environmental Health Perspectives; Carolyn Klinge, PhD, Endocrine Disruptors; B. Paige Lawrence, PhD, Endocrine Disruptors; Adrian V. Lee, PhD, Endocrinology; J. P. Myers, PhD, Endocrine Disruptors; Randy J. Nelson, PhD, Hormones and Behavior; Miquel Porta, MD, MPH, PhD, Journal of Epidemiology & Community Health; European Journal of Clinical Investigation; European Journal of Epidemiology; Merrily Poth, MD, Journal of Clinical Endocrinology and Metabolism; Gail S. Prins PhD, Endocrinology; Andrology; Emilie F. Rissman, PhD, Endocrinology; Paul E. Sawchenko, PhD, Journal of Comparative Neurology; Olle Söder, MD, PhD, Hormone Research in Pediatrics; Ana M. Soto, MD, Progress in Biophysics and Molecular Biology; Shanna Swan, PhD, Endocrine Disruptors; Hugh S. Taylor, MD, Endocrinology; Manuel Tena-Sempere, MD, PhD, Endocrinology; Frederick vom Saal, PhD, Endocrine Disruptors; Zuoxin Wang, PhD, Hormones and Behavior; Wade V. Welshons, PhD, Endocrine Disruptors; R. Thomas Zoeller, PhD, Endocrine Disruptors. Additional Signatories: Benson T. Akingbemi, PhD; Koji Arizono, PhD; Scott M. Belcher, PhD; Fiorella Belpoggi, PhD; Carl-Gustaf Bornehag, PhD; Jean-Pierre Bourguignon, MD, PhD; Terry R. Brown, PhD; Ernesto Burgio, MD; Terrence J. Collins, PhD; D. Andrew Crain, PhD; Barbara Demeneix, PhD; Rodney R. Dietert, PhD; Loretta Doan, PhD; Thea M. Edwards, PhD; Mariana F. Fernandez, PhD; R. William Field, PhD, MS; Linda C. Giudice, MD, PhD; Louis J. Guillette, PhD; Y. Leon Guo, MD, PhD, MPH; Tyrone Hayes, PhD; Andrea Hinwood, PhD; C. Vyvyan Howard, MB, ChB, PhD, FRCPath; Eric R. Hugo, PhD; Patricia Hunt, PhD; Taisen Iguchi, PhD; Richard J. Jackson, MD, MPH, AIA (Hon), ASLA (Hon); Patricia Joseph-Bravo, PhD; Hans Laufer, PhD; Duk-Hee Lee, MD, PhD; Rachel Morello-Frosch, PhD, MPH; Jane Muncke, PhD; Angel Nadal, PhD; David O. Norris, PhD; Jörg Oehlmann, PhD; Nicolas Olea, MD, PhD; Edward F. Orlando, PhD; Vasantha Padmanabhan, PhD; Paola Palanza, PhD; Stefano Parmigiani, PhD; Donald W. Pfaff, PhD; Beverly S. Rubin, PhD; Joan V. Ruderman, PhD; Arnold Schecter, MD, MPH; Toshi Shioda, MD, PhD; Martin Scheringer, PhD; Niels E. Skakkebaek, MD; Howard M. Snyder III, MD; Carlos Sonnenschein, MD; Richard W. Stahlhut, MD, MPH; Laura Vandenberg, PhD; Catherine VandeVoort, PhD; Martin Wagner, PhD; Hong-Sheng Wang, PhD; Bernard Weiss, PhD; Teresa Woodruff, PhD; Tracey Woodruff, PhD." @default.
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• W2978222783 date "2013-10-24" @default.
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• W2978222783 title "Policy decisions on endocrine disruptors should be based on science across disciplines: a response to Dietrichet al." @default.
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