Matches in SemOpenAlex for { <https://semopenalex.org/work/W2978223086> ?p ?o ?g. }
- W2978223086 endingPage "413" @default.
- W2978223086 startingPage "403" @default.
- W2978223086 abstract "Trauma-related disorders, such as posttraumatic stress disorder (PTSD) are remarkably common and debilitating, and are often characterized by dysregulated threat responses. Across numerous epidemiological studies, females have been found to have an approximately twofold increased risk for PTSD and other stress-related disorders. Understanding the biological mechanisms of this differential risk is of critical importance. Recent data suggest that the pituitary adenylate cyclase-activating polypeptide (PACAP) pathway is a critical regulator of the stress response across species. Moreover, increasing evidence suggests that this pathway is regulated by both stress and estrogen modulation and may provide an important window into understanding mechanisms of sex differences in the stress response. We have recently shown that PACAP and its receptor (PAC1R) are critical mediators of abnormal processes after psychological trauma. Notably, in heavily traumatized human subjects, there appears to be a robust sex-specific association of PACAP blood levels and PAC1R gene variants with fear physiology, PTSD diagnosis, and symptoms, specifically in females. The sex-specific association occurs within a single-nucleotide polymorphism (rs2267735) that resides in a putative estrogen response element involved in PAC1R gene regulation. Complementing these human data, the PAC1R messenger RNA is induced with fear conditioning or estrogen replacement in rodent models. These data suggest that perturbations in the PACAP-PAC1R pathway are regulated by estrogen and are involved in abnormal fear responses underlying PTSD." @default.
- W2978223086 created "2019-10-10" @default.
- W2978223086 creator A5069398670 @default.
- W2978223086 creator A5083258080 @default.
- W2978223086 date "2016-12-31" @default.
- W2978223086 modified "2023-09-27" @default.
- W2978223086 title "Stress-related disorders, pituitary adenylate cyclase—activating peptide (PACAP)ergic system, and sex differences" @default.
- W2978223086 cites W1625944144 @default.
- W2978223086 cites W1633358180 @default.
- W2978223086 cites W1652429153 @default.
- W2978223086 cites W1848237869 @default.
- W2978223086 cites W1915403575 @default.
- W2978223086 cites W1919362256 @default.
- W2978223086 cites W1966475217 @default.
- W2978223086 cites W1967643044 @default.
- W2978223086 cites W1969052595 @default.
- W2978223086 cites W1975765156 @default.
- W2978223086 cites W1979067492 @default.
- W2978223086 cites W1981739333 @default.
- W2978223086 cites W1983793618 @default.
- W2978223086 cites W1984131837 @default.
- W2978223086 cites W1985900540 @default.
- W2978223086 cites W1986636573 @default.
- W2978223086 cites W1987123448 @default.
- W2978223086 cites W1988104308 @default.
- W2978223086 cites W1988538650 @default.
- W2978223086 cites W1988611008 @default.
- W2978223086 cites W1990652217 @default.
- W2978223086 cites W1991182470 @default.
- W2978223086 cites W1992701656 @default.
- W2978223086 cites W1997932742 @default.
- W2978223086 cites W2000584602 @default.
- W2978223086 cites W2000843844 @default.
- W2978223086 cites W2002922392 @default.
- W2978223086 cites W2005190428 @default.
- W2978223086 cites W2012861810 @default.
- W2978223086 cites W2014199091 @default.
- W2978223086 cites W2023771120 @default.
- W2978223086 cites W2024949012 @default.
- W2978223086 cites W2026443131 @default.
- W2978223086 cites W2026836897 @default.
- W2978223086 cites W2029574115 @default.
- W2978223086 cites W2030063067 @default.
- W2978223086 cites W2031587794 @default.
- W2978223086 cites W2033650768 @default.
- W2978223086 cites W2033847645 @default.
- W2978223086 cites W2034346264 @default.
- W2978223086 cites W2035101579 @default.
- W2978223086 cites W2036863219 @default.
- W2978223086 cites W2038356227 @default.
- W2978223086 cites W2039283104 @default.
- W2978223086 cites W2041588928 @default.
- W2978223086 cites W2044592212 @default.
- W2978223086 cites W2045496652 @default.
- W2978223086 cites W2046222481 @default.
- W2978223086 cites W2047479500 @default.
- W2978223086 cites W2047523044 @default.
- W2978223086 cites W2047924165 @default.
- W2978223086 cites W2048595206 @default.
- W2978223086 cites W2048851179 @default.
- W2978223086 cites W2050237761 @default.
- W2978223086 cites W2051000959 @default.
- W2978223086 cites W2056487077 @default.
- W2978223086 cites W2057279566 @default.
- W2978223086 cites W2058112769 @default.
- W2978223086 cites W2058940618 @default.
- W2978223086 cites W2060978874 @default.
- W2978223086 cites W2063157049 @default.
- W2978223086 cites W2064910482 @default.
- W2978223086 cites W2068294188 @default.
- W2978223086 cites W2068480672 @default.
- W2978223086 cites W2072944527 @default.
- W2978223086 cites W2073135091 @default.
- W2978223086 cites W2078229830 @default.
- W2978223086 cites W2079334198 @default.
- W2978223086 cites W2081926681 @default.
- W2978223086 cites W2085770121 @default.
- W2978223086 cites W2087353002 @default.
- W2978223086 cites W2090019039 @default.
- W2978223086 cites W2090849704 @default.
- W2978223086 cites W2092354644 @default.
- W2978223086 cites W2100896177 @default.
- W2978223086 cites W2102377062 @default.
- W2978223086 cites W2103345644 @default.
- W2978223086 cites W2103498835 @default.
- W2978223086 cites W2103569380 @default.
- W2978223086 cites W2103881507 @default.
- W2978223086 cites W2104625179 @default.
- W2978223086 cites W2111407966 @default.
- W2978223086 cites W2112444654 @default.
- W2978223086 cites W2116116525 @default.
- W2978223086 cites W2119432249 @default.
- W2978223086 cites W2121454015 @default.
- W2978223086 cites W2122526826 @default.
- W2978223086 cites W2125530647 @default.
- W2978223086 cites W2137873417 @default.
- W2978223086 cites W2148503178 @default.
- W2978223086 cites W2148616431 @default.