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- W2978232364 abstract "G protein-coupled receptor(GPCR),superfamily represent some of the most successful targets of modern drug therapy,with proven significant efficacy in a broad range of human conditions and disease processes.It has recently been appreciated that β-arrestins,once viewed simply as regulators of GPCR desensitization,act as multifunctional adapter proteins that mediate distinct intracellular signals.Moreover,β-arrestin-mediated signaling has distinct functional and biochemical consequences from that mediated by G proteins.With the discovery of β-arrestin-mediated signaling has come a new appreciation of G protein-and β-arrestin-biased ligans.These ligands are not only useful tools for investigating the biochemistry of GPCR signalling,they also have the potential to be developed into new classes of therapeutics.Therefore,this article will mainly review the property,mechanism,pharmacological effects of biased ligands and the new research technologies." @default.
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- W2978232364 date "2012-01-01" @default.
- W2978232364 modified "2023-09-24" @default.
- W2978232364 title "Selective functions of GPCR biased ligands" @default.
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