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• W2978238460 abstract "Despite remission of clinical symptoms postpartum, women who have had preeclampsia demonstrate microvascular endothelial dysfunction, mediated in part by increased sensitivity to angiotensin II (ANG II). Angiotensin-(1–7) [Ang-(1–7)] is an endogenous inhibitor of the actions of ANG II and plausible druggable target in women who had preeclampsia. We therefore examined the therapeutic potential of Ang-(1–7) in the microvasculature of women with a history of preeclampsia (PrEC; n = 13) and parity-matched healthy control women (HC; n = 13) hypothesizing that administration of Ang-(1–7) would increase endothelium-dependent dilation and nitric oxide (NO)-dependent dilation and decrease ANG II-mediated constriction in PrEC. Using the cutaneous microcirculation, we assessed endothelium-dependent vasodilator function in response to graded infusion of acetylcholine (ACh; 10 −7 to 10 2 mmol/L) in control sites and sites treated with 15 mmol/L N G -nitro-l-arginine methyl ester (l-NAME; NO-synthase inhibitor), 100 µmol/L Ang-(1–7), or 15 mmol/L l-NAME + 100 µmol/L Ang-(1–7). Vasoconstrictor function was measured in response to ANG II (10 −20 -10 −4 mol/L) in control sites and sites treated with 100 µmol/L Ang-(1–7). PrEC had reduced endothelium-dependent dilation ( P < 0.001) and NO-dependent dilation ( P = 0.04 vs. HC). Ang-(1–7) coinfusion augmented endothelium-dependent dilation ( P < 0.01) and NO-dependent dilation ( P = 0.03) in PrEC but had no effect in HC. PrEC demonstrated augmented vasoconstrictor responses to ANG II ( P < 0.01 vs. HC), which was attenuated by coinfusion of Ang-(1–7) ( P < 0.001). Ang-(1–7) increased endothelium-dependent vasodilation via NO synthase-mediated pathways and attenuated ANG II-mediated constriction in women who have had preeclampsia, suggesting that Ang-(1–7) may be a viable therapeutic target for improved microvascular function in women who have had a preeclamptic pregnancy." @default.
• W2978238460 created "2019-10-10" @default.
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• W2978238460 date "2020-01-01" @default.
• W2978238460 modified "2023-10-16" @default.
• W2978238460 title "Local angiotensin-(1–7) administration improves microvascular endothelial function in women who have had preeclampsia" @default.
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• W2978238460 doi "https://doi.org/10.1152/ajpregu.00221.2019" @default.
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