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- W2978251565 abstract "Objective:To investigate the expression and clinical/pathologic significance of B7-1 and MICA gene in human hepatocellular carcinoma (HCC),and the correlation with hepatitis virus (HBV) thereof. Methods:The B7-1 and MICA gene were selected by bioinformatics analysis. Then samples were detected by immunohistochemistry and analyzed for the semiquantitative assignment by a rapid computer method. The expression of HBV in serum was detected by ELISA. The patients were divided into groups by the clinical stage and the duration of follow-up visit. Results:Two genes were both expressed in hepatocytes, hepatoma cells and part of lymphocytes. In clinical stage, the rate of MICA gene was lower along with the progress of clinical stage and the positive rate increase in tumor and hepatocyte near the tumor (P 0.05). In classification of histology, B7-1 gene was decreased. The positive rate of MICA gene was significantly higher in HCC compared with that of HBV (P 0.01). The positive rate of B7-1 gene in HCC was increased along with the increased duration of survival time without tumor (P 0.05). The correlation between MICA / B7-1 gene and HBsAg was negative. The rate of MICA gene of hepatocyte was less in HBV group than that of HCC group(χ2 = 4.02,P 0.05)for showing that the effect of HBeAb. The expression of B7-1 gene was increased in lymphocytic stroma (χ2 = 5.11,P 0.05). The expression of B7-1 gene was higher only in hepatoma cell in persistent HBV infection. Conclusion: The B7-1 gene has closed relationship with prognoses of HCC. The HBV could be an important fact for antineoplastic action of MICA and B7-1 gene in HCC." @default.
- W2978251565 created "2019-10-10" @default.
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- W2978251565 date "2009-01-01" @default.
- W2978251565 modified "2023-09-23" @default.
- W2978251565 title "Correlation between the Expression of B7-1 and MICA Gene in Human Hepatocellular Carcinoma and Hepatitis B Virus" @default.
- W2978251565 hasPublicationYear "2009" @default.
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